| Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women. | |
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MedLine Citation:
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PMID: 8475226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years). GH and PRL secretion was studied in five women after DSIP (25 micrograms/kg bw IV over 30 min), arginine chlorhydrate (0.5 g/kg bw IV over 30 min) and simultaneous DSIP plus arginine chlorhydrate administration. In three other women the circadian rhythm of GH and PRL was studied during DSIP (25 micrograms/kg bw from 2130h to 2230h) and placebo IV infusion. Serum GH and PRL levels were normal under basal conditions and no effects were noted after the infusion of DSIP. The GH and PRL circadian rhythm was not modified by DSIP administration. DSIP did not influence GH and PRL responsiveness to arginine chlorhydrate. We found that at dosages which are known to modify ECG patterns, DSIP is unable to modify spontaneous or arginine chlorhydrate-induced GH and PRL secretion. |
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Authors:
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M Giusti; A Carraro; E Porcella; S Valenti; D Nicora; P Sessarego; G Giordano |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 18 ISSN: 0306-4530 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 1993 |
Date Detail:
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Created Date: 1993-05-14 Completed Date: 1993-05-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 79-84 Citation Subset: IM |
Affiliation:
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DISEM, Cattedra di Endocrinologia, Università di Genova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Arginine / pharmacology Delta Sleep-Inducing Peptide / adverse effects, pharmacology* Electrocardiography Female Follicle Stimulating Hormone / blood Growth Hormone / blood* Humans Hydrocortisone / blood Luteinizing Hormone / blood Prolactin / blood* |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 69431-45-4/Delta Sleep-Inducing Peptide; 74-79-3/Arginine; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-72-6/Growth Hormone |
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