Document Detail


Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis.
MedLine Citation:
PMID:  11390359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The body axes of Drosophila are established during oogenesis through reciprocal interactions between the germ line cells and the somatic follicle cells that surround them. The Notch pathway is required at two stages in this process: first, for the migration of the follicle cells around the germ line cyst and, later, for the polarization of the anterior-posterior (A-P) axis of the oocyte. Its function in these events, however, has remained controversial. Using clonal analysis, we show that Notch signaling controls cell proliferation and differentiation in the whole follicular epithelium. Notch mutant follicle cells remain in a precursor state and fail to switch from the mitotic cell cycle to the endocycle. Furthermore, removal of Delta from the germ line produces an identical phenotype, showing that Delta signals from the germ cells to control the timing of follicle cell differentiation. This explains the axis formation defects in Notch mutants, which arise because undifferentiated posterior follicle cells cannot signal to polarize the oocyte. Delta also signals from the germ line to Notch in the soma earlier in oogenesis to control the differentiation of the polar and stalk follicle cells. The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control.
Authors:
H López-Schier; D St Johnston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  15     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-06     Completed Date:  2001-07-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1393-405     Citation Subset:  IM    
Affiliation:
Wellcome/CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Movement / genetics,  physiology
Drosophila
Drosophila Proteins*
Female
Fluorescent Antibody Technique
Germ Cells / cytology*,  physiology
Insect Proteins / genetics,  physiology
Membrane Proteins / genetics,  physiology*
Mitosis
Oogenesis / genetics,  physiology*
Ovarian Follicle / cytology*,  physiology
Ovum / cytology,  physiology
Phenotype
Receptors, Cell Surface / genetics,  physiology
Receptors, Notch
Signal Transduction / genetics,  physiology
Trans-Activators / genetics,  physiology
Transforming Growth Factor alpha*
Transforming Growth Factors / genetics,  physiology
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Insect Proteins; 0/Membrane Proteins; 0/Receptors, Cell Surface; 0/Receptors, Notch; 0/Trans-Activators; 0/Transforming Growth Factor alpha; 0/delta protein; 0/gurken protein, Drosophila; 0/notch protein, Drosophila; 76057-06-2/Transforming Growth Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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