| Delta relaxation enhanced MR: improving activation-specificity of molecular probes through R1 dispersion imaging. | |
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MedLine Citation:
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PMID: 19189292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MR molecular imaging enables high-resolution, in vivo study of molecular processes frequently utilizing gadolinium-based probes that specifically bind to a particular biological molecule or tissue. While some MR probes are inactive when unbound and produce enhancement only after binding, the majority are less specific and cause enhancement in either state. Accumulation processes are then required to increase probe concentration in regions of the target molecule/tissue. Herein, a method is described for creating specificity for traditionally nonspecific probes. This method utilizes MR field-cycling methods to produce MRI contrast related to the dependence of R(1) upon magnetic field. It is shown that the partial derivative of R(1) with respect to magnetic field strength, R(1)', can be used as an unambiguous measure of probe binding. T(1)-weighted images and R(1)' images were produced for samples of albumin and buffer both enhanced with the albumin-binding agent Vasovist. For T(1) images, samples with low concentrations of Vasovist in an albumin solution could not be differentiated from samples with higher concentrations of Vasovist in buffer. Conversely, the R(1)' images showed high specificity to albumin. Albumin samples with a 10-microM concentration of Vasovist were enhanced over buffer samples containing up to 16 times more Vasovist. |
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Authors:
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Jamu K Alford; Brian K Rutt; Timothy J Scholl; William B Handler; Blaine A Chronik |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 61 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-31 Completed Date: 2009-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 796-802 Citation Subset: IM |
Affiliation:
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Department of Physics and Astronomy, University of Western Ontario, London, ON, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Gadolinium / analysis*, metabolism* Image Enhancement / methods* Magnetic Resonance Imaging / methods* Magnetic Resonance Spectroscopy / methods* Molecular Probe Techniques* Organometallic Compounds / analysis*, metabolism* Rabbits Serum Albumin / analysis*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Organometallic Compounds; 0/Serum Albumin; 0/gadofosveset trisodium; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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