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Delta-like 1 Homologue (DLK1) is a Hypothalamus-Enriched Protein that is Present in Orexin-, but not Melanin-Concentrating Hormone-Containing Neurones, of the Lateral Hypothalamic Area.
MedLine Citation:
PMID:  23387476     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Delta-like 1 homologue (DLK1), also known as preadipocyte factor-1 (Pref-1), fetal antigen (FA1) or pG2, is a transmembrane protein belonging to the epidermal growth factor (EGF)-like superfamily. The protein becomes soluble and biologically active after cleavage of the TACE enzyme. DLK1 is involved in the differentiation of several cell types, including adipocytes. Lack of the dlk1 gene in mice results in adiposity and a polymorphism within the gene encoding DLK1 has been associated with obesity. The dlk1 gene is expressed in restricted areas of the central nervous system with an enrichment of cell bodies expressing DLK1 mRNA in the hypothalamus. Goat and rabbit antisera to DLK1 were used to study the cellular localization and chemical identity of DLK1-immunoreactive neuronal cell bodies in rat hypothalamus. DLK1 immunoreactivity was demonstrated in the cell bodies of the suprachiasmatic, supraoptic, paraventricular, arcuate nuclei and in the lateral hypothalamus. At the subcellular level, DLK1 immunoreactivity was observed in the cell soma and dendrites, but not in axonal fibers or nerve terminals. Double-labeling of sections from the lateral hypothalamic/perifornical area of colchicine-treated rats, a treatment that increases the content of immunoreactive material in the cell soma, showed that DLK1 was present in the virually all orexin- and dynorphin-containing neurons. In contrast, DLK1 was not demonstrated in any melanin-concentrating hormone (MCH)- or cocaine- and amphetamine-regulated transcript (CART)-containing neurons of the lateral hypothalamic/perifornical area. The presence of DLK1 in a population of lateral hypothalamic neurons, suggest a functional role for DLK1 in orexin/hypocretin/dynorphin neurons. © 2013 British Society for Neuroendocrinology.
Authors:
B Meister; M Perez; T Daraio
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 British Society for Neuroendocrinology.
Affiliation:
Department of Neuroscience, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
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