Document Detail

Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine.
MedLine Citation:
PMID:  12969205     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the cystic fibrosis (CF) delta-F508 gene mutation predisposes to intussusception, and so selects infants who should not receive rotavirus vaccine. METHODS: Stored neonatal screening blood spots, retrieved from 81 infants with intussusception and from 79 controls, were tested for the presence of the CF delta-F508 gene mutation. RESULTS: Prevalence of the mutation was similar in blood specimens from intussusception patients and from controls. CONCLUSION: Testing for the CF delta-F508 mutation at birth is unlikely to identify infants predisposed to intussusception, and therefore is not relevant to rotavirus vaccine programs.
G Barnes; A Srivastava; J Carlin; I Francis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  39     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-09-12     Completed Date:  2004-03-04     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  516-7     Citation Subset:  IM    
The Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Australia.
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MeSH Terms
Cystic Fibrosis / blood,  genetics*
Heterozygote Detection
Infant, Newborn
Intussusception / blood,  etiology*
Neonatal Screening*
Odds Ratio
Rotavirus Vaccines / administration & dosage*
Reg. No./Substance:
0/Rotavirus Vaccines
Comment In:
J Paediatr Child Health. 2003 Sep-Oct;39(7):507-8   [PMID:  12969202 ]
J Paediatr Child Health. 2004 May-Jun;40(5-6):327-8; author reply 328   [PMID:  15151596 ]

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