Document Detail


Delta-9-tetrahydrocannabinol: localization in body fat.
MedLine Citation:
PMID:  4682965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[(14)C]Delta(9)-Tetrahydrocannabinol (Delta(9)THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Delta(9)THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Delta(9)THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Delta(9)THC and its metabolites accumulated in fat and brain.
Authors:
D S Kreuz; J Axelrod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  179     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1973 Jan 
Date Detail:
Created Date:  1973-03-02     Completed Date:  1973-03-02     Revised Date:  2011-12-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Animals
Brain / metabolism
Cannabis / metabolism*
Carbon Isotopes
Female
Injections, Subcutaneous
Liver / metabolism
Lung / metabolism
Rats
Tetrahydrocannabinol / administration & dosage,  metabolism
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 1972-08-3/Tetrahydrocannabinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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