Document Detail

Delta-9-tetrahydrocannabinol (THC) fails to stimulate consumption of a highly palatable food in the rat.
MedLine Citation:
PMID:  9489514     Owner:  NLM     Status:  MEDLINE    
THC is the active chemical component in marijuana. In humans, it is known to cause acute sedation, alterations of cognition, and to stimulate appetite. The goal of this study was to determine if THC would produce acute stimulation of the consumption of a highly-palatable food item in the rat. Separate groups of rats were administered THC (1.0 or 2.0 mg/kg) either 30, 60, or 120 min or saline 30 min prior to being placed in the presence of a highly palatable food (Nilla Wafers soaked in water). Spontaneous exploration decreased at the 2.0 mg/kg dose of THC at the 60 min time point. The amount of food eaten was not significantly changed at either dose. These results do not support the hypothesis that THC causes acute appetite stimulation in the rat. However, some other non-specific effect of THC that indirectly reduced food consumption without directly acting upon appetite is a possible explanation that cannot be presently excluded, and that will need to be assessed in future studies.
T J Graceffo; J K Robinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  62     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1998  
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  PL85-8     Citation Subset:  IM    
Department of Psychology, State University of New York at Stony Brook, 11794-2500, USA.
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MeSH Terms
Appetite / drug effects*
Rats, Sprague-Dawley
Tetrahydrocannabinol / pharmacology*
Reg. No./Substance:

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