Document Detail


Delivery systems for hormone replacement therapy.
MedLine Citation:
PMID:  16506947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The steroid hormones used for hormone replacement therapy in the menopausal transition and postmenopause can be administered by several different routes using a variety of delivery systems. The conventional approach to administration has been oral, and this is still the standard against which other routes are compared. However, there is a steadily increasing research development and popularity for alternative systems. Such systems can be geared to ultra low-dose delivery for local vaginal effect or higher dosages for systemic effect. Different delivery systems have a range of attributes with varying appeal to different individual women. Such a range of choices can be important for acceptability and compliance. One of the most important attributes of many newer delivery systems is the potential to deliver hormones in a controlled manner over prolonged periods of time, allowing constant low dosages, as well as constant blood and tissue levels. They also have the potential for reducing side effects and metabolic effects. Transdermal, subdermal, intravaginal and intrauterine systems are particularly likely to undergo refinement and further development in the foreseeable future with subsequent increases in popularity.
Authors:
Ian S Fraser; Diana Mansour
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  3     ISSN:  1742-5247     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-04-13     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  191-204     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, University of Sydney, NSW 2006, Australia. helena@med.usyd.edu.au
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MeSH Terms
Descriptor/Qualifier:
Dosage Forms*
Drug Administration Routes
Female
Hormone Replacement Therapy*
Humans
Chemical
Reg. No./Substance:
0/Dosage Forms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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