Document Detail

Delivery outcome in relation to maternal use of some recently introduced antidepressants.
MedLine Citation:
PMID:  18004128     Owner:  NLM     Status:  MEDLINE    
Little is known concerning possible hazards of maternal use of the recently introduced antidepressant drugs with noradrenergic and varying serotonergic activity (serotonin-noradrenaline reuptake inhibitor [SNRI]/noradrenergic reuptake inhibitor [NRI] drugs). Using the Swedish Medical Birth Registry, we identified 732 women who had used SNRI/NRI drugs in early pregnancy. Maternal characteristics were studied as well as delivery outcome: pregnancy duration, birth weight, neonatal diagnoses, infant deaths, and congenital malformations. Comparisons were made with all deliveries in the population (n = 860,215) after adjustment for identified confounders, and risks were expressed as odds ratios or (when numbers were low) as risk ratios. Women using SNRI/NRI deviated from other women by being older, more often having their first infant, being more extensive smokers, having a higher body mass index, and more often being born within Sweden. These characteristics, like the pattern of concomitant drug use, resembled much those of women using selective serotonin reuptake inhibitor (SSRI) drugs. The rate of preterm births was significantly increased (odds ratio, 1.6; 95% confidence interval, 1.19-2.15), and neonatal symptoms such as respiratory problems, low Apgar score, hypoglycemia, and neonatal convulsions showed a similar pattern as seen after maternal SSRI treatment. We found no increased risk for stillbirths or congenital malformations. Delivery outcome after exposure to SNRI/NRI drugs resembles much what has been described after use of SSRI drugs. No signs of teratogenicity were found.
Roland Lennestål; Bengt Källén
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  27     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-02-26     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  607-13     Citation Subset:  IM    
Department of Clinical Pharmacology, Norrland University Hospital, Umeå, Sweden.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  etiology
Abortion, Spontaneous / epidemiology,  etiology
Adrenergic Uptake Inhibitors / adverse effects
Antidepressive Agents / adverse effects*
Birth Weight / drug effects
Cyclohexanols / adverse effects
Databases, Factual / statistics & numerical data
Delivery, Obstetric / statistics & numerical data*
Gestational Age
Infant Mortality
Infant, Newborn
Mianserin / adverse effects,  analogs & derivatives
Morpholines / adverse effects
Pregnancy Trimester, First / drug effects
Prenatal Exposure Delayed Effects / chemically induced*,  epidemiology
Registries / statistics & numerical data
Serotonin Uptake Inhibitors / adverse effects
Smoking / adverse effects
Sweden / epidemiology
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Antidepressive Agents; 0/Cyclohexanols; 0/Morpholines; 0/Serotonin Uptake Inhibitors; 24219-97-4/Mianserin; 61337-67-5/mirtazapine; 93413-69-5/venlafaxine; 98769-81-4/reboxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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