| Delivery outcome in relation to maternal use of some recently introduced antidepressants. | |
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MedLine Citation:
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PMID: 18004128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known concerning possible hazards of maternal use of the recently introduced antidepressant drugs with noradrenergic and varying serotonergic activity (serotonin-noradrenaline reuptake inhibitor [SNRI]/noradrenergic reuptake inhibitor [NRI] drugs). Using the Swedish Medical Birth Registry, we identified 732 women who had used SNRI/NRI drugs in early pregnancy. Maternal characteristics were studied as well as delivery outcome: pregnancy duration, birth weight, neonatal diagnoses, infant deaths, and congenital malformations. Comparisons were made with all deliveries in the population (n = 860,215) after adjustment for identified confounders, and risks were expressed as odds ratios or (when numbers were low) as risk ratios. Women using SNRI/NRI deviated from other women by being older, more often having their first infant, being more extensive smokers, having a higher body mass index, and more often being born within Sweden. These characteristics, like the pattern of concomitant drug use, resembled much those of women using selective serotonin reuptake inhibitor (SSRI) drugs. The rate of preterm births was significantly increased (odds ratio, 1.6; 95% confidence interval, 1.19-2.15), and neonatal symptoms such as respiratory problems, low Apgar score, hypoglycemia, and neonatal convulsions showed a similar pattern as seen after maternal SSRI treatment. We found no increased risk for stillbirths or congenital malformations. Delivery outcome after exposure to SNRI/NRI drugs resembles much what has been described after use of SSRI drugs. No signs of teratogenicity were found. |
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Authors:
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Roland Lennestål; Bengt Källén |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 27 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-02-26 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 607-13 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Norrland University Hospital, Umeå, Sweden. rl@pharm.umu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology Abortion, Spontaneous / epidemiology, etiology Adrenergic Uptake Inhibitors / adverse effects Antidepressive Agents / adverse effects* Birth Weight / drug effects Cyclohexanols / adverse effects Databases, Factual / statistics & numerical data Delivery, Obstetric / statistics & numerical data* Female Gestational Age Humans Infant Mortality Infant, Newborn Mianserin / adverse effects, analogs & derivatives Morpholines / adverse effects Pregnancy Pregnancy Trimester, First / drug effects Prenatal Exposure Delayed Effects / chemically induced*, epidemiology Registries / statistics & numerical data Serotonin Uptake Inhibitors / adverse effects Smoking / adverse effects Sweden / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Uptake Inhibitors; 0/Antidepressive Agents; 0/Cyclohexanols; 0/Morpholines; 0/Serotonin Uptake Inhibitors; 24219-97-4/Mianserin; 61337-67-5/mirtazapine; 93413-69-5/venlafaxine; 98769-81-4/reboxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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