| Delivery of modulated electron beams with conventional photon multi-leaf collimators. | |
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MedLine Citation:
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PMID: 19098355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electron beam radiotherapy is an accepted method to treat shallow tumors. However, modulation of electrons to customize dose distributions has not readily been achieved. Studies of bolus and tertiary collimation systems have been met with limitations. We pursue the use of photon multi-leaf collimators (MLC) for modulated electron radiotherapy (MERT) to achieve customized distributions for potential clinical use. As commercial planning systems do not support the use of MLC with electrons, planning was conducted using Monte Carlo calculations. Segmented and dynamic modulated delivery of multiple electron segments was configured, calculated and delivered for validation. Delivery of electrons with segmented or dynamic leaf motion was conducted. A phantom possessing an idealized stepped target was planned and optimized with subsequent validation by measurements. Finally, clinical treatment plans were conducted for post-mastectomy and cutaneous lymphoma of the scalp using forward optimization techniques. Comparison of calculations and measurements was successful with agreement of +/-2%/2 mm for the energies, segment sizes, depths tested for delivered segments for the dynamic and segmented delivery. Clinical treatment plans performed provided optimal dose coverage of the target while sparing distal organs at risk. Execution of plans using an anthropomorphic phantom to ensure safe and efficient delivery was conducted. Our study validates that MERT is not only possible using the photon MLC, but the efficient and safe delivery inherent with the dynamic delivery provides an ideal technique for shallow tumor treatment. |
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Authors:
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Eric E Klein; Maria Mamalui-Hunter; Daniel A Low |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2008-12-19 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 54 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 327-39 Citation Subset: IM |
Affiliation:
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Washington University, St. Louis, MO, USA. eklein@radonc.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biophysical Phenomena Electrons / therapeutic use* Female Humans Neoplasms / radiotherapy Particle Accelerators Phantoms, Imaging / statistics & numerical data Photons Radiotherapy Planning, Computer-Assisted / statistics & numerical data Radiotherapy, Conformal / instrumentation, methods*, statistics & numerical data Thoracic Wall / radiation effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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