Document Detail

Delivery of maternal thyroid hormones to the fetus.
MedLine Citation:
PMID:  21414798     Owner:  NLM     Status:  Publisher    
Thyroid hormones (THs) play an essential role in ensuring normal fetal development, particularly that of the central nervous system. Before 16weeks gestation, the fetus relies solely on transplacental delivery of maternal T(4), and clinical studies suggest that even mild maternal thyroid hormone deficiency adversely affects the intellectual function of offspring. Maternofetal TH transfer is regulated by trophoblast cell membrane transporters, which mediate influx and efflux of THs, placental deiodinases D3 and D2, which control intraplacental TH levels, and TH-binding proteins (transthyretin), which provide transport roles in the placenta. This review discusses new information about mechanisms of transplacental delivery of T(4) to the fetus, providing insight into complex processes that are vitally important for normal fetal development.
Jatin Patel; Kelly Landers; Huika Li; Robin H Mortimer; Kerry Richard
Related Documents :
21244618 - Haemodynamic effects of long-term administration of sildenafil in normotensive pregnant...
10572858 - Estradiol and progesterone metabolite concentration in white-tailed deer (odocoileus vi...
15336698 - Biosynthesis and catabolism of prostaglandin f2alpha (pgf2alpha) are controlled by prog...
21210478 - Maternal thyroid function at 11-13 weeks of gestation in fetal trisomies 21 and 18.
23921858 - Use of withdrawal and unintended pregnancy among females 15-24 years of age.
23644858 - Conjoined twins: twenty years' experience at a reference center in brazil.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  -     ISSN:  1879-3061     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
School of Medicine, University of Queensland, Herston 4006, Brisbane, Australia; Conjoint Endocrine Laboratory, Royal Brisbane and Women's Hospital, Herston, 4029, Brisbane, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of salt stress induced changes in Photosystem II heterogeneity by prompt fluorescence and d...
Next Document:  Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-depe...