Document Detail


Delivery of maternal thyroid hormones to the fetus.
MedLine Citation:
PMID:  21414798     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Thyroid hormones (THs) play an essential role in ensuring normal fetal development, particularly that of the central nervous system. Before 16weeks gestation, the fetus relies solely on transplacental delivery of maternal T(4), and clinical studies suggest that even mild maternal thyroid hormone deficiency adversely affects the intellectual function of offspring. Maternofetal TH transfer is regulated by trophoblast cell membrane transporters, which mediate influx and efflux of THs, placental deiodinases D3 and D2, which control intraplacental TH levels, and TH-binding proteins (transthyretin), which provide transport roles in the placenta. This review discusses new information about mechanisms of transplacental delivery of T(4) to the fetus, providing insight into complex processes that are vitally important for normal fetal development.
Authors:
Jatin Patel; Kelly Landers; Huika Li; Robin H Mortimer; Kerry Richard
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  -     ISSN:  1879-3061     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
School of Medicine, University of Queensland, Herston 4006, Brisbane, Australia; Conjoint Endocrine Laboratory, Royal Brisbane and Women's Hospital, Herston, 4029, Brisbane, Australia.
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