Document Detail


Delivery after transfer of frozen-thawed embryos from in vitro-matured oocytes in a woman at risk for ovarian hyperstimulation syndrome.
MedLine Citation:
PMID:  17139133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present report describes the birth of a healthy infant after cryopreservation of embryos produced from in vitro-matured oocytes retrieved from a woman at risk of developing ovarian hyperstimulation syndrome (OHSS) during conventional in vitro fertilization (IVF) cycles. A conventional long protocol including gonadotropin-releasing hormone agonist (GnRHa) and gonadotropins induced a risk of OHSS. Oocyte retrieval was performed on day 11 of the cycle, and 27 immature oocytes were obtained. Following incubation for 24 h in maturation medium, 74.1% (20/27) of the oocytes were at the metaphase II stage. Fourteen oocytes (14/20, 70.0%) were fertilized after intracytoplasmic sperm injection (ICSI) with her husband's spermatozoa and cultured for 3 days. On day 4 following oocyte retrieval, three embryos at the 8-16 cell stage were transferred into the woman's uterus, and five spare embryos were frozen. Since the fresh embryo transfer failed to result in pregnancy, three post-thaw embryos were transferred into the woman three months later. Transfer of the frozen embryos resulted in pregnancy with delivery of a healthy infant girl.
Authors:
Juan Chen; Yun Qian; Ting Feng; Ling-Bo Cai; Jia-Yin Liu; Yan Zhang; Wei Ding; Yun-Dong Mao
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-01
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  53     ISSN:  0916-8818     ISO Abbreviation:  J. Reprod. Dev.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-17     Completed Date:  2007-06-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  449-53     Citation Subset:  IM    
Affiliation:
Jiangsu Province Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cells, Cultured
Cryopreservation*
Delivery, Obstetric*
Embryo Transfer*
Embryo, Mammalian / physiology*
Female
Humans
Oocytes / cytology,  physiology*
Ovarian Hyperstimulation Syndrome / etiology
Pregnancy
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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