| Delirium: Is sleep important? | |
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MedLine Citation:
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PMID: 23040286 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Delirium and poor sleep quality are common and often co-exist in hospitalised patients. A link between these disorders has been hypothesised but whether this link is a cause-and-effect relationship or simply an association resulting from shared mechanisms is yet to be determined. Potential shared mechanisms include: abnormalities of neurotransmitters, tissue ischaemia, inflammation and sedative exposure. Sedatives, while decreasing sleep latency, often cause a decrease in slow wave sleep and stage rapid eye movement (REM) sleep and therefore may not provide the same restorative properties as natural sleep. Mechanical ventilation, an important cause of sleep disruption in intensive care unit (ICU) patients, may lead to sleep disruption not only from the discomfort of the endotracheal tube but also as a result of ineffective respiratory efforts and by inducing central apnoea events if not properly adjusted for the patient's physiologic needs. When possible, efforts should be made to optimise the patient-ventilator interaction to minimise sleep disruptions. |
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Authors:
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Paula L Watson; Piero Ceriana; Francesco Fanfulla |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Best practice & research. Clinical anaesthesiology Volume: 26 ISSN: 1878-1608 ISO Abbreviation: Best Pract Res Clin Anaesthesiol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101121446 Medline TA: Best Pract Res Clin Anaesthesiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 355-66 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, Division of Allergy, Pulmonary, Critical Care and Sleep Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: paula.l.watson@vanderbilt.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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