| Delineation of behavioral phenotypes in genetic syndromes: characteristics of autism spectrum disorder, affect and hyperactivity. | |
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MedLine Citation:
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PMID: 21080217 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4-51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes. |
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Authors:
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Chris Oliver; Katy Berg; Jo Moss; Kate Arron; Cheryl Burbidge |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of autism and developmental disorders Volume: 41 ISSN: 1573-3432 ISO Abbreviation: J Autism Dev Disord Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: United States |
Other Details:
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Languages: eng Pagination: 1019-32 Citation Subset: IM |
Affiliation:
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Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK, c.oliver@bham.ac.uk. |
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