| Delineating the cellular pathways of hematopoietic lineage commitment. | |
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MedLine Citation:
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PMID: 18752972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver. |
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Authors:
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Sidinh Luc; Natalija Buza-Vidas; Sten Eirik W Jacobsen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-08-27 |
Journal Detail:
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Title: Seminars in immunology Volume: 20 ISSN: 1044-5323 ISO Abbreviation: Semin. Immunol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-01-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 213-20 Citation Subset: IM |
Affiliation:
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Haematopoietic Stem Cell Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Stem Cells
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classification Animals Cell Differentiation / physiology* Cell Lineage / physiology* Fetal Stem Cells / classification Hematopoietic Stem Cells / classification, cytology*, physiology* Humans Models, Biological* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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