Document Detail


Delimitation of the time of death by immunohistochemical detection of thyroglobulin.
MedLine Citation:
PMID:  10842031     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To improve the possibilities to delimit the time of death after longer laytime it was examined if this is possible by immunohistochemical detection of thyroglobulin. The results show that in our examination material the colloid and the follicular cells of the thyroid glands of up to 5-day-old corpses produce a positive immunoreaction towards thyroglobulin in all cases whereas none of the corpses older than 13 days show such a reaction. This means that in case of a negative immunoreaction the time of death can be assumed to lie more than 6 days before the autopsy. The fact that a negative immunoreaction occurs consistently after 13 days leads to the conclusion that when thyroglobulin has been stained in a specimen, the death of the respective person must lie a maximum of 12 days earlier, whereby these time-limits may change in considerably different surrounding conditions.
Authors:
F Wehner; H D Wehner; M C Schieffer; J Subke
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Forensic science international     Volume:  110     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-01     Completed Date:  2000-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Affiliation:
Institut für Gerichtliche Medizin der Universität Tübingen, Nägelestrasse 5, D-72074, Tübingen, Germany. frank.wehner@uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Death*
Humans
Immunohistochemistry
Postmortem Changes
Thyroglobulin / analysis*
Thyroid Gland / chemistry*
Time Factors
Chemical
Reg. No./Substance:
9010-34-8/Thyroglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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