Document Detail


Deletion polymorphism of ACE gene is associated with higher blood pressure after hospitalization in normotensive subjects.
MedLine Citation:
PMID:  10821127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure has been shown to decrease in response to hospital admission. Several parameters including the decline of sympathetic nervous activity and negative sodium balance have been shown to be involved in this phenomenon. We investigated genetic influence on office BP and BP after hospitalization. One hundred and sixty-three men from the general population, free from antihypertensive medication, were enrolled in the present study. They stayed at the hospital for general medical check-up. BP was measured on the day of admission, and again the following day. Mean systolic blood pressure was significantly decreased after hospitalization from 117.3 +/- 9.9 mmHg to 115.3 +/- 12.8 mmHg (p=0.042). Subjects with DD+ID genotype showed a significantly higher systolic blood pressure after hospitalization than that of subjects with genotype II. There were no genotype specific differences in diastolic blood pressure or changes in blood pressure by the administration. In summary, systolic blood pressure after hospitalization was significantly higher in normotensive male subjects who possessed the D allele of ACE I/D polymorphism.
Authors:
K Uemura; K Kohara; J Nakura; T Miki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  23     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-04     Completed Date:  2000-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Blood Pressure / genetics*
Gene Deletion*
Genotype
Hospitalization*
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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