Document Detail


Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia.
MedLine Citation:
PMID:  11086181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infant leukemia below the age of 12 months is a rare disease that exhibits a high frequency of 11q23 rearrangements. We assessed the presence of polymorphisms in several metabolic genes in 23 families of infants diagnosed with leukemia under 12 months of age in Italy. When polymorphism frequencies were calculated within families, frequencies of GST gene deletions were significantly higher than expected only among the parents of infants without the 11q23 rearrangement. These data suggest that the deletion of GST genes in parents may affect the risk of infant leukemia through a pathway independent of the MLL gene.
Authors:
S Garte; E Taioli; F Crosti; L Sainati; E Barisone; M Luciani; M Jankovic; A G Biondi
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Leukemia research     Volume:  24     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  971-4     Citation Subset:  IM    
Affiliation:
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
Chromosomes, Human, Pair 11*
Cytochrome P-450 CYP1A1 / genetics
Cytochrome P-450 CYP2E1 / genetics
DNA-Binding Proteins / genetics*
Female
Gene Deletion*
Gene Rearrangement
Genetic Predisposition to Disease*
Genomic Imprinting*
Glutathione Transferase / genetics*
Humans
Infant
Isoenzymes / genetics
Italy
Leukemia, Myeloid, Acute / genetics*
Male
Myeloid-Lymphoid Leukemia Protein
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Proto-Oncogenes*
Transcription Factors*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Isoenzymes; 0/MLL protein, human; 0/Transcription Factors; 149025-06-9/Myeloid-Lymphoid Leukemia Protein; EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 1.14.14.1/Cytochrome P-450 CYP2E1; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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