| Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation. | |
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MedLine Citation:
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PMID: 16171284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: The finding that deletion or mutation of core circadian clock genes in both mice and flies induce unexpected alterations in sleep amount, sleep architecture and the recovery response to sleep deprivation, has led to new insights into functions of the circadian system that extend beyond its role as a regulator of the timing of the sleep-wake cycle. A key transcription factor in the transcriptional/translational feedback loop of mammalian circadian genes is BMAL1/Mop3, a heterodimeric partner to CLOCK. It was previously shown that mice deficient in the BMAL1/Mop3 gene become immediately arrhythmic in constant darkness and have reduced locomotor activity levels under entrained and constant conditions. In this study, we tested the hypothesis that the mammalian BMAL1/Mop3 gene would have regulatory effects on sleep-wake patterns. DESIGN: In mice with targeted deletion of the BMAL1/Mop3 gene, EEG/EMG sleep-wake patterns were recorded under entrained and free-running conditions as well as following acute (6-hrs) sleep deprivation. MEASUREMENTS AND RESULTS: Mice homozygous for the BMAL1/Mop3 deletion showed an attenuated rhythm of sleep and wakefulness distribution across the 24-hr period. In addition, these mice showed increases in total sleep time, sleep fragmentation and EEG delta power under baseline conditions, and an attenuated compensatory response to acute sleep deprivation. CONCLUSIONS: These new data strengthen the hypothesis that molecular components of the circadian system play a central role in the generation of sleep and wakefulness beyond just the timing of these behavioral vigilance states. |
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Authors:
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Aaron Laposky; Amy Easton; Christine Dugovic; Jacqueline Walisser; Christopher Bradfield; Fred Turek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Sleep Volume: 28 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-09-20 Completed Date: 2005-12-15 Revised Date: 2011-05-17 |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: United States |
Other Details:
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Languages: eng Pagination: 395-409 Citation Subset: IM |
Affiliation:
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Neurobiology and Physiology, Northwestern University, 2205 Tech Drive Hogan 2-160, Evanston, IL 60208-3520, USA. a-laposky@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ARNTL Transcription Factors Alleles Animals Basic Helix-Loop-Helix Transcription Factors / genetics* Body Temperature / physiology Circadian Rhythm / physiology* Electroencephalography Electromyography Genotype Male Mice Mice, Inbred C57BL Polysomnography Sleep Deprivation / genetics* Sleep Stages / physiology Sleep, REM / physiology |
| Chemical | |
Reg. No./Substance:
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0/ARNTL Transcription Factors; 0/Arntl protein, mouse; 0/Basic Helix-Loop-Helix Transcription Factors |
| Comments/Corrections | |
Comment In:
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Sleep. 2005 Apr;28(4):389-91
[PMID:
16171282
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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