Document Detail


Deletion, insertion and translocation of DNA sequences contribute to chromosome size polymorphism in Plasmodium berghei.
MedLine Citation:
PMID:  1343732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extensive chromosome size polymorphism arises in Plasmodium berghei during in vivo mitotic multiplication. Size differences between homologous chromosomes mainly involve rearrangements in the subtelomeric regions while internal chromosomal regions are more conserved. Size differences are almost exclusively due to differences in the copy number of a 2.3 kb subtelomeric repeat unit. Not only deletion of 2.3 kb repeats occurs, but addition of new copies of this repeat sometimes results in the formation of enlarged chromosomes. Even chromosomes which originally lack 2.3 kb repeats, can acquire these during mitotic multiplication. In one karyotype mutant, 2.3 kb repeats were inserted within one of the original telomeres of chromosome 4, creating an internal stretch of telomeric repeats. Chromosome translocation can contribute to chromosome size polymorphism as well. We found a karyotype mutant in which chromosome 7 with a size of about 1.4 Mb is translocated to chromosome 13/14 with a size of about 3 Mb, resulting in a rearranged chromosome, which was shown to contain a junction between internal DNA sequences of chromosome 13/14 and subtelomeric 2.3 kb repeats of chromosome 7. In this mutant a new chromosome of 1.4 Mb is present which consists of part of chromosome 13/14.
Authors:
C J Janse; B Mons
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Memórias do Instituto Oswaldo Cruz     Volume:  87 Suppl 3     ISSN:  0074-0276     ISO Abbreviation:  Mem. Inst. Oswaldo Cruz     Publication Date:  1992  
Date Detail:
Created Date:  1994-03-11     Completed Date:  1994-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502619     Medline TA:  Mem Inst Oswaldo Cruz     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Affiliation:
Laboratory of Parasitology, University of Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosomes / ultrastructure*
Crossing Over, Genetic
DNA, Protozoan / genetics*
Gene Rearrangement
Mitosis
Molecular Sequence Data
Plasmodium berghei / genetics*,  ultrastructure
Polymorphism, Genetic
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Sequence Deletion*
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/DNA, Protozoan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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