| Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. | |
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MedLine Citation:
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PMID: 19723628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SLC26A7 (human)/Slc26a7 (mouse) is a recently identified chloride-base exchanger and/or chloride transporter that is expressed on the basolateral membrane of acid-secreting cells in the renal outer medullary collecting duct (OMCD) and in gastric parietal cells. Here, we show that mice with genetic deletion of Slc26a7 expression develop distal renal tubular acidosis, as manifested by metabolic acidosis and alkaline urine pH. In the kidney, basolateral Cl(-)/HCO3(-) exchange activity in acid-secreting intercalated cells in the OMCD was significantly decreased in hypertonic medium (a normal milieu for the medulla) but was reduced only mildly in isotonic medium. Changing from a hypertonic to isotonic medium (relative hypotonicity) decreased the membrane abundance of Slc26a7 in kidney cells in vivo and in vitro. In the stomach, stimulated acid secretion was significantly impaired in isolated gastric mucosa and in the intact organ. We propose that SLC26A7 dysfunction should be investigated as a potential cause of unexplained distal renal tubular acidosis or decreased gastric acid secretion in humans. |
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Authors:
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Jie Xu; Penghong Song; Suguru Nakamura; Marian Miller; Sharon Barone; Seth L Alper; Brigitte Riederer; Janina Bonhagen; Lois J Arend; Hassane Amlal; Ursula Seidler; Manoocher Soleimani |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-01 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 284 ISSN: 1083-351X ISO Abbreviation: J. Biol. Chem. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2009-11-23 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 29470-9 Citation Subset: IM |
Affiliation:
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Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Renal Tubular
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genetics,
metabolism* Animals Chloride-Bicarbonate Antiporters* Gastric Acid / secretion* Gastric Mucosa / secretion* Humans Hydrogen-Ion Concentration Kidney Medulla / metabolism* Mice Mice, Knockout Mice, Mutant Strains |
| Grant Support | |
ID/Acronym/Agency:
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DK 43495/DK/NIDDK NIH HHS; DK62809/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chloride-Bicarbonate Antiporters; 0/Slc26a7 protein, mouse |
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