Document Detail


Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion.
MedLine Citation:
PMID:  19723628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SLC26A7 (human)/Slc26a7 (mouse) is a recently identified chloride-base exchanger and/or chloride transporter that is expressed on the basolateral membrane of acid-secreting cells in the renal outer medullary collecting duct (OMCD) and in gastric parietal cells. Here, we show that mice with genetic deletion of Slc26a7 expression develop distal renal tubular acidosis, as manifested by metabolic acidosis and alkaline urine pH. In the kidney, basolateral Cl(-)/HCO3(-) exchange activity in acid-secreting intercalated cells in the OMCD was significantly decreased in hypertonic medium (a normal milieu for the medulla) but was reduced only mildly in isotonic medium. Changing from a hypertonic to isotonic medium (relative hypotonicity) decreased the membrane abundance of Slc26a7 in kidney cells in vivo and in vitro. In the stomach, stimulated acid secretion was significantly impaired in isolated gastric mucosa and in the intact organ. We propose that SLC26A7 dysfunction should be investigated as a potential cause of unexplained distal renal tubular acidosis or decreased gastric acid secretion in humans.
Authors:
Jie Xu; Penghong Song; Suguru Nakamura; Marian Miller; Sharon Barone; Seth L Alper; Brigitte Riederer; Janina Bonhagen; Lois J Arend; Hassane Amlal; Ursula Seidler; Manoocher Soleimani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-01
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  284     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2009-11-23     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29470-9     Citation Subset:  IM    
Affiliation:
Research Services, Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA.
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MeSH Terms
Descriptor/Qualifier:
Acidosis, Renal Tubular / genetics,  metabolism*
Animals
Chloride-Bicarbonate Antiporters*
Gastric Acid / secretion*
Gastric Mucosa / secretion*
Humans
Hydrogen-Ion Concentration
Kidney Medulla / metabolism*
Mice
Mice, Knockout
Mice, Mutant Strains
Grant Support
ID/Acronym/Agency:
DK 43495/DK/NIDDK NIH HHS; DK62809/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Chloride-Bicarbonate Antiporters; 0/Slc26a7 protein, mouse
Comments/Corrections

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