Document Detail


Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia.
MedLine Citation:
PMID:  8438156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.
Authors:
C L Willman; C E Sever; M G Pallavicini; H Harada; N Tanaka; M L Slovak; H Yamamoto; K Harada; T C Meeker; A F List
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  259     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-22     Completed Date:  1993-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  968-71     Citation Subset:  IM    
Affiliation:
University of New Mexico School of Medicine, Department of Pathology, Albuquerque 87131.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Blotting, Southern
Chromosome Mapping*
Chromosomes, Human, Pair 5*
DNA Probes
DNA-Binding Proteins / genetics*
Gene Deletion*
Gene Rearrangement
Genes, Tumor Suppressor*
Humans
In Situ Hybridization
Interferon Regulatory Factor-1
Leukemia / genetics*
Molecular Sequence Data
Myelodysplastic Syndromes / genetics*
Phosphoproteins / genetics*
Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
CA-32102/CA/NCI NIH HHS; CA-32734/CA/NCI NIH HHS; DK-43042/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA Probes; 0/DNA-Binding Proteins; 0/IRF1 protein, human; 0/Interferon Regulatory Factor-1; 0/Phosphoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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