Document Detail


Deletion 7q22 in uterine leiomyoma. A cytogenetic review.
MedLine Citation:
PMID:  8275445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytogenetic patterns of uterine leiomyomas have been extensively investigated, and cases characterized by specific clonal changes have been documented in detail. In these tumors one of the cytogenetic changes frequently observed has been a del(7), particularly del(7)(q22), usually as a sole anomaly. This is confirmed by our experience and by reports in the literature. The fact that del(7) is one of the most common abnormalities in leiomyoma raises the question of its role in tumor development. The main purpose of this review is to analyze the above aspect and to interpret its possible meaning. Our findings on cytogenetic abnormalities of chromosome 7 in leiomyoma, together with those reported in the literature, are reviewed and discussed. A listing of the genes located at 7q22 is also presented.
Authors:
Y Y Ozisik; A M Meloni; U Surti; A A Sandberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  71     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-04     Completed Date:  1994-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Deletion*
Chromosomes, Human, Pair 7*
Female
Humans
Leiomyoma / genetics*
Uterine Neoplasms / genetics*
Grant Support
ID/Acronym/Agency:
CA 41183/CA/NCI NIH HHS

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