Document Detail

Deleterious effects of vasodilating agents. Induction of subendocardial ischemia in dogs with proximal stenosis of coronary artery.
MedLine Citation:
PMID:  7161879     Owner:  NLM     Status:  MEDLINE    
This study was designed to determine how distal vasodilatory stimuli can alter coronary hemodynamics and the appearance of myocardial ischemia in the presence of severe coronary stenosis. In anesthetized open chest dogs, left circumflex coronary artery (LCx) flow, distal LCx perfusion pressure (DCPP), heart rate, and aortic pressure were monitored and regional myocardial ischemia was estimated from ST segment deviation in the epicardial and intramyocardial electrograms obtained from the electrodes located in the area supplied by LCx. In the presence of severe LCx constriction, intracoronary administration of adenosine (0.01 mg/Kg/min) and dipyridamole (0.05 mg/Kg) failed to augment LCx flow and induced further reduction in DCPP without changing systemic hemodynamics. In parallel with these hemodynamic changes, significant ST elevation was observed in the inner layer of the area supplied by the LCx. These results show that subepicardial vasodilation following vasodilatory stimuli can induce transmural flow redistribution and lead to subendocardial ischemia in the presence of severe coronary stenosis.
S Kawashima; M Yokoyama; S Sakamoto; T Okada; H Akita; T Mizutani; H Fukuzaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  23     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  951-60     Citation Subset:  IM    
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MeSH Terms
Adenosine / toxicity
Constriction, Pathologic
Coronary Disease / chemically induced*,  physiopathology
Coronary Vessels / drug effects
Dipyridamole / toxicity
Hemodynamics / drug effects
Vasodilator Agents / toxicity*
Reg. No./Substance:
0/Vasodilator Agents; 58-32-2/Dipyridamole; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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