| Deleterious effects of endotoxin on cultured endothelial cells: an in vitro model of vascular injury. | |
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MedLine Citation:
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PMID: 6268539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of endotoxin-triggered granulocytes on the viability of endothelial cells in vitro was investigated. Endotoxin or its lipid A component caused granulocytes to adhere to and significantly damage cultured endothelial cells. Fresh serum is not necessary but does amplify both adherence and endothelial injury. Much of the endothelial injury was inhibited by free-radical scavengers or by blocking granulocyte adhesion to endothelial cells and appears to result from free radical production by the stimulated granulocyte. Studies in this model suggest a pathogenic role for the endotoxin-triggered granulocyte in the Shwartzman reaction and perhaps related clinical disorders. |
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Authors:
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O Yamada; C F Moldow; T Sacks; P R Craddock; M A Boogaerts; H S Jacob |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Inflammation Volume: 5 ISSN: 0360-3997 ISO Abbreviation: Inflammation Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1981-11-24 Completed Date: 1981-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600105 Medline TA: Inflammation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 115-26 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Toxins
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pharmacology* Cells, Cultured Chromium Radioisotopes / diagnostic use Endothelium / drug effects*, metabolism Escherichia coli* Humans Hydrogen Peroxide / metabolism, pharmacology Lipid A / pharmacology Lipopolysaccharides / pharmacology* Neutrophils / drug effects, metabolism Superoxides / metabolism, pharmacology Umbilical Veins |
| Grant Support | |
ID/Acronym/Agency:
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AM 15730/AM/NIADDK NIH HHS; CA 13722/CA/NCI NIH HHS; HL 18725/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Chromium Radioisotopes; 0/Lipid A; 0/Lipopolysaccharides; 11062-77-4/Superoxides; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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