Document Detail

Deleterious effect of zinc in a pig model of acute endotoxemia.
MedLine Citation:
PMID:  15385258     Owner:  NLM     Status:  MEDLINE    
By antiapoptotic effects and the induction of the heat-shock response, zinc is supposed to be a promising means of therapy during sepsis. As zinc also stimulates the expression of proinflammatory cytokines, its administration during the proinflammatory stage of septic shock might have adverse effects. Therefore, this study analyzes the influence of zinc during the acute phase of endotoxemia. In a pig model of acute endotoxemia, animals were divided into two groups: group I (n = 5) with saline treatment and group II (n = 5) with zinc treatment in close succession to lipopolysaccharide (LPS) (1.0 mu g/kg Escherichia coli endotoxin WO 111:B4). Hemodynamic and pulmonary monitoring was followed by combined reflection photometry, pulse oxymetry, blood gas samples, and temperature measurement. Plasma concentrations of tumor necrosis factor (TNF)alpha and interleukin (IL)-6 were analyzed by enzyme-linked immunosorbent assay (ELISA). Morphology included the weight of the lungs, the width of the alveolar septae, and the paracentral necrosis rate of the liver. After LPS infusion, group II (zinc) showed an impressive and significant deterioration of all pulmonary and most of the hemodynamical parameters compared to group I (saline). Levels of TNFalpha and IL-6 measured were significantly higher after zinc treatment. In accordance, we found significant more morphologic damages in group II (zinc). The almost simultaneous infusion of zinc and LPS complementary induced proinflammatory effects with a deleterious outcome. The same potentials characterizing zinc as a promising tool of prophylactic therapy in sepsis seem to ban its use during the acute phase.
Carsten Krones; Bernd Klosterhalfen; Volker Fackeldey; Karsten Junge; Rafael Rosch; Robert Schwab; Michael Stumpf; Uwe Klinge; Volker Schumpelick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  17     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-09-23     Completed Date:  2005-02-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
Department of Surgery, Technical University of Aachen, Aachen, Germany.
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MeSH Terms
Acute Disease
Endotoxemia / drug therapy*
Enzyme-Linked Immunosorbent Assay
Heat-Shock Response / drug effects
Interleukin-6 / analysis
Lipopolysaccharides / toxicity
Lung / physiopathology
Systemic Inflammatory Response Syndrome / prevention & control
Tumor Necrosis Factor-alpha / analysis
Zinc / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Interleukin-6; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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