Document Detail

The Deleted in Colorectal Cancer netrin guidance system: a molecular strategy for neuronal navigation.
MedLine Citation:
PMID:  10499167     Owner:  NLM     Status:  MEDLINE    
1. Neuronal migration is one of the principal events in laying out the architectural plan of the embryonic central nervous system (CNS). In addition, the correct navigation of axonal growth cones to their specific targets is essential for the establishment of the intricate network of axon projections found within the mature CNS. 2. The Deleted in Colorectal Cancer (DCC) guidance receptor, together with its ligands, the netrins, is now emerging as a major navigational system driving both neuronal and axonal migrations. Members of the netrin family of secreted guidance cues are also likely to be ligands for a second DCC-like receptor, neogenin. 3. The present paper reviews the current understanding of DCC-netrin-dependent axon pathfinding within the embryonic spinal cord and suggests novel modes of action for both DCC and neogenin.
H M Cooper; J M Gad; S L Keeling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  26     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-26     Completed Date:  1999-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  749-51     Citation Subset:  IM    
Ludwig Institute for Cancer Research, Parkville, Victoria, Australia.
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MeSH Terms
Cell Adhesion Molecules / physiology*
Neurons / physiology*
Receptors, Cell Surface / physiology*
Spinal Cord / embryology*
Tumor Suppressor Proteins*
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/DCC protein, human; 0/Receptors, Cell Surface; 0/Tumor Suppressor Proteins; 0/netrin receptors

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