Document Detail


Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise cycle outcome in patients receiving donated oocytes: a randomized study.
MedLine Citation:
PMID:  16818032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the initiation of P supplementation as artificial luteal phase support (day -1, day 0, or day +1 of egg donation) in extensive programs of ovum donation influences cycle cancellation, pregnancy outcome, and implantation rate in day 3 embryo transfers. DESIGN: Prospective randomized trial. SETTING: Oocyte donation program at the Instituto Valenciano de Infertilidad, Valencia, Spain. PATIENT(S): Three hundred recipients with normal ovarian function, absence of uterine anomalies, and undergoing their first egg donation were recruited between September 2003 and September 2004. INTERVENTION(S): A computer-based randomization divided the recipients into three groups when hCG was administered to their matched donors. The first group (group A) started P supplementation the day before oocyte retrieval; the second group (group B) started P supplementation on the day of the oocyte retrieval; and the third group (group C) started P supplementation 1 day after the egg retrieval once fertilization was confirmed. MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and ongoing pregnancy rates were the primary outcome measures considered. The secondary outcome measure was the cancellation rate, especially due to fertilization failure. RESULT(S): Global cancellation rate and cancellation rate due to fertilization failure were significantly higher in group A (12.4% and 8.2%, respectively) than in group C (3.3% and 0%, respectively). Reproductive outcome was similar in all the groups except for a higher biochemical pregnancy rate in group A (12.9%) than in groups B (6.6%) and C (2.3%). CONCLUSION(S): Initiation of P on day +1 of embryo development decreases cancellation rates of day 3 embryo transfers in extensive programs of ovum donation without any deleterious effect on pregnancy outcome or implantation rate.
Authors:
María-José Escribá; José Bellver; Ernesto Bosch; María Sánchez; Antonio Pellicer; José Remohí
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  86     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
Affiliation:
Universitary Institute IVI Valencia, Valencia, Spain. mjescriba@ivi.es
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chemotherapy, Adjuvant
Drug Administration Schedule
Female
Fertilization in Vitro / methods,  statistics & numerical data*
Humans
Incidence
Infertility, Female / epidemiology*,  therapy*
Oocyte Donation / methods,  statistics & numerical data*
Ovulation / drug effects
Ovulation Induction / methods,  statistics & numerical data*
Pregnancy
Pregnancy Rate*
Progesterone / administration & dosage*
Spain / epidemiology
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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