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Delayed villous maturation of the placenta - quantitative assessment in different cohorts.
MedLine Citation:
PMID:  23137099     Owner:  NLM     Status:  Publisher    
Abstract OBJECTIVE: Placental villous maturation is maximal in the third trimester with an abundance of terminal villi. Delayed villous maturation (DVM) of the placenta is associated with chromosomal abnormalities, gestational diabetes and an adverse outcome. The aim of this study was to compare quantitative assessment of vasculo-syncytial membranes in cases of liveborn infants, perinatal deaths and controls. METHODS: Cases were selected as following: (1). liveborn infants with a qualitative diagnosis of DVM (n=15); (2). controls matched for gestational age whose placentas did not have DVM (n = 15); (3) stillbirths (SB) / neonatal deaths (NND) showing DVM (n=13); and (4) stillbirths from autopsies where DVM was felt to be the cause of death (COD) (n=12). Vasculo-syncytial membranes (VSM) were counted in ten terminal villi in each of ten consecutive high power fields on three slides. Data analysis was carried out using SPSS. RESULTS: Liveborn cases with DVM showed statistically significantly less VSM than controls (mean 1.01 vs. 2.42, p <0.0001). The SB / NND group also showed significantly less VSM than the control group (mean 0.46 vs. 2.42, p<0.0001) and less than the liveborn DVM group (mean 0.46 vs. 1.01, p=0.001). The COD group was significantly different to the control group (mean 0.42 vs. 2.42, p<0.0001) and the liveborn DVM group (mean 0.42 vs. 1.01, p<0.0001) but not significantly different to the SB / NND group. CONCLUSION: There is a quantitative reduction in vasculo-syncytial membranes in cases of DVM compared to controls.
Ann Deborah Treacy; Mary Frances Higgins; John Kearney; Fionnuala M McAuliffe; Eoghan Mooney
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a National Maternity Hospital, Histopathology.
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