Document Detail

Delayed treatment with magnesium: reduction of brain infarction and improvement of electrophysiological recovery following transient focal cerebral ischemia in rats.
MedLine Citation:
PMID:  16028768     Owner:  NLM     Status:  MEDLINE    
OBJECT: The authors examined whether delayed treatment with Mg++ would reduce brain infarction and improve electrophysiological and neurobehavioral recovery following cerebral ischemia-reperfusion. METHODS: Male Sprague-Dawley rats were subjected to right middle cerebral artery occlusion for 90 minutes followed by 72 hours of reperfusion. Magnesium sulfate (750 micromol/kg) or vehicle was given via intracarotid infusion at the beginning of reperfusion. Neurobehavioral outcome and somatosensory evoked potentials (SSEPs) were examined before and 72 hours after ischemia-reperfusion. Brain infarction was assessed after the rats had died. Before ischemia-reperfusion, stable SSEP waveforms were recorded after individual fore- and hindpaw stimulations. At 72 hours of perfusion the SSEPs recorded from ischemic fore- and hindpaw cortical fields were depressed in vehicle-injected animals and the amplitudes decreased to 19 and 27% of baseline, respectively (p < 0.001). Relative to controls, the amplitudes of SSEPs recorded from both ischemic fore- and hindpaw cortical field in the Mg++-treated animals were significantly improved by 23% (p < 0.005) and 39% (p < 0.001) of baselines, respectively. In addition, Mg++ improved sensory and motor neurobehavioral outcomes by 34% (p < 0.01) and 24% (p < 0.05), respectively, and reduced cortical (p < 0.05) and striatal (p < 0.05) infarct sizes by 42 and 36%, respectively. CONCLUSIONS: Administration of Mg++ at the commencement of reperfusion enhances electrophysiological and neurobehavioral recovery and reduces brain infarction after cerebral ischemia-reperfusion. Because Mg++ has already been used clinically, it may be worthwhile to investigate it further to see if it holds potential benefits for patients with ischemic stroke and for those who will undergo carotid endarterectomy.
E-Jian Lee; Ming-Yang Lee; Guan-Liang Chang; Li-Hsuan Chen; Yu-Ling Hu; Tsung-Ying Chen; Tian-Shung Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  102     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-20     Completed Date:  2005-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1085-93     Citation Subset:  AIM; IM    
Neurophysiology Laboratory, Neurosurgical Service, Department of Surgery and Institute of Biomedical Engineering, National Cheng Kung University Medical Center and Medical School, Tainan, Taiwan.
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MeSH Terms
Behavior, Animal
Cerebral Cortex / pathology,  physiopathology
Corpus Striatum / pathology,  physiopathology
Evoked Potentials, Somatosensory*
Infarction, Middle Cerebral Artery / drug therapy*,  pathology,  physiopathology
Injections, Intra-Arterial
Ischemic Attack, Transient / drug therapy*,  pathology,  physiopathology
Magnesium / pharmacology*
Rats, Sprague-Dawley
Recovery of Function / drug effects*
Stroke / drug therapy,  pathology,  physiopathology
Time Factors
Reg. No./Substance:

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