Document Detail

Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury.
MedLine Citation:
PMID:  18954879     Owner:  NLM     Status:  MEDLINE    
Delayed post-anoxic encephalopathy has rarely been reported, and has most commonly been associated with carbon monoxide poisoning. The underlying pathophysiological mechanism is unknown. We describe a patient with a delayed neurologic decline after a good initial recovery from a hypoxic-ischemic event precipitated by acute blood loss. MRI revealed early globus pallidus necrosis followed by delayed substantia nigra damage and leukoencephalopathy. We suggest that anemia might play a role in this pattern of hypoxic-ischemic brain injury.
Min Lou; Chao-Hui Jing; Magdy H Selim; Louis R Caplan; Mei-Ping Ding
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-26
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  277     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  147-9     Citation Subset:  IM    
Department of neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, China.
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MeSH Terms
Anemia / complications,  pathology
Dementia, Vascular / complications,  pathology*
Globus Pallidus / pathology
Hypoxia-Ischemia, Brain / complications,  pathology*
Magnetic Resonance Imaging
Middle Aged
Substantia Nigra / pathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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