| Delayed replication of Xq27 in individuals with the fragile X syndrome. | |
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MedLine Citation:
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PMID: 1415338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The timing of late replicating bands on the X chromosome has been studied in individuals with the fragile X [fra(X)] syndrome. Compared to controls both affected individuals and symptomless carriers of the syndrome show delayed replication of the Xq27 region as shown by 2 different methods. The implications of this finding are discussed in relation to the proposal [Laird et al., 1987] that the fraX syndrome is associated with a failure to reactivate the Xq27 band correctly after it has been inactivated in a female. |
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Authors:
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T Webb |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 43 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-11-13 Completed Date: 1992-11-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1057-62 Citation Subset: IM |
Affiliation:
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Department of Clinical Genetics, University of Birmingham, Birmingham Maternity Hospital, Edgbaston, England, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA
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chemistry,
genetics DNA Replication* Dosage Compensation, Genetic Female Fragile X Syndrome / genetics* Humans Male Methylation Models, Genetic X Chromosome* |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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