Document Detail

Delayed repair of facial nerve trauma: an experimental study in guinea pigs.
MedLine Citation:
PMID:  23768060     Owner:  NLM     Status:  In-Data-Review    
Abstract Conclusion: The curative effect in the group where facial-facial anastomosis (FFA) was delayed for 7 days was similar to that in the immediate FFA group and had a better repair within 60 days. Objective: Due to the uncertainty about optimal timing of delayed facial nerve repair, we designed an experimental study in guinea pigs to find out the cut-off duration for delayed nerve repair. Methods: In this study, 64 male guinea pigs were randomly divided into 8 groups: normal, immediate FFA, and delayed FFA for 7, 14, 21, 30, 60, and 90 days (n = 6). Two months after suture of the nerves, the passing rate of myelinated fibers growing from the proximal to the distal stumps was calculated. Results: The passing rates of myelinated fibers in the groups with immediate FFA and FFA delayed for 7 days were significantly higher than those in other delayed FFA groups and the difference was statistically significant (p < 0.05), whereas the passing rates of the groups where FFA was delayed for 60 and 90 days were apparently lower than those of the immediate FFA and other delayed FFA groups. Under the electron microscope, regenerated fibers of the groups with immediate FFA and FFA delayed for 7 days were very similar to the normal myelinated fibers.
Jiongjiong Hu; Liang Zhou; Zhaoxin Ma
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  133     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  England    
Other Details:
Languages:  eng     Pagination:  772-8     Citation Subset:  IM    
Department of Otorhinolaryngology, Shanghai East Hospital, Tongji University , Shanghai.
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