Document Detail

Delayed recovery of thyrotropin responsiveness after radioactive iodine therapy for hyperthyroidism.
MedLine Citation:
PMID:  10875293     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: After radioactive iodine therapy for hyperthyroidism, an expected lag in the responsiveness of thyrotropin (TSH) is 60 to 90 days. In our experience, however, many patients seemed to have a more prolonged lag in TSH recovery. METHODS: A retrospective chart review was performed in 58 patients who underwent radioactive iodine therapy for hyperthyroidism (52 with Graves disease, 5 with toxic nodular goiters, and 1 with a toxic adenoma). RESULTS: Forty-nine patients (84%) had appropriate responses of TSH for their level of serum thyroid hormone. Thirty-one became hypothyroid, 12 became euthyroid, and 6 remained hyperthyroid. Nine patients (16%) had a lag in their TSH responsiveness. The TSH remained low for 3 months in 5 patients, for 9 months in 3 patients, and 1 patient had low levels of serum TSH for at least 12 months. CONCLUSIONS: After radioactive iodine therapy for hyperthyroidism, decisions upon further therapy must be based upon the clinical status as well as the serum levels of TSH and thyroid hormones.
S G Albert; H M Goodgold; J Chehade; J Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  319     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-10     Completed Date:  2000-07-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  376-9     Citation Subset:  AIM; IM    
Department of Internal Medicine, St. Louis University School of Medicine, MO 63104, USA.
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MeSH Terms
Hyperthyroidism / blood*,  radiotherapy*
Iodine Radioisotopes / therapeutic use*
Middle Aged
Recovery of Function
Retrospective Studies
Thyroid Hormones / blood*
Thyrotropin / blood*
Time Factors
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Thyroid Hormones; 9002-71-5/Thyrotropin

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