Document Detail

Delayed radiation necrosis of the central nervous system in patients irradiated for pituitary tumours.
MedLine Citation:
PMID:  1431959     Owner:  NLM     Status:  MEDLINE    
Four cases of delayed radiation necrosis involving the CNS were found in a group of 46 patients irradiated for pituitary tumours over a six year period. This occurred in three of 11 patients with Cushing's disease representing an incidence of 27% in this group. There were no cases among 11 patients with acromegaly or among seven with prolactinomas. One case (6%) was found in the 17 patients with chromophobe adenomas. Standard doses of radiation were delivered to these patients and the findings support suggestions that the metabolic disturbances of Cushing's disease may reduce tolerance to radiation. Our results and a literature review indicate that if radiotherapy is used to treat Cushing's disease, the total dose should be less than 50 Gy at 2 Gy per day fractionation.
P J Grattan-Smith; J G Morris; A O Langlands
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  55     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  949-55     Citation Subset:  IM    
Department of Neurology, Westmead Hospital, Sydney, Australia.
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MeSH Terms
Adenoma / radiotherapy*
Brain / pathology,  radiation effects*
Cushing Syndrome / radiotherapy
Follow-Up Studies
Magnetic Resonance Imaging
Mental Recall / radiation effects
Middle Aged
Neurologic Examination / radiation effects
Neuropsychological Tests
Pituitary Irradiation / adverse effects*
Pituitary Neoplasms / radiotherapy*
Radiation Dosage
Radiation Injuries / diagnosis*,  pathology
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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