Document Detail

Delayed preattentional functioning in early psychosis patients with cannabis use.
MedLine Citation:
PMID:  22402706     Owner:  NLM     Status:  Publisher    
RATIONALE: Cannabis use is prevalent among the early psychosis (EP) population. The event-related potentials, mismatch negativity (MMN) and P3a are reduced in EP. Cannabinoids have been shown to modulate N-methyl-D-aspartate receptors which are involved in MMN generation. OBJECTIVES: This study is the first to investigate the effects of cannabis use on MMN/P3a in EP. METHODS: EP was defined as a history of psychosis or psychotic symptoms with no progression to date to chronic schizophrenia. Twenty-two EP patients with cannabis use (EP + CANN), 22 non-cannabis-using EP patients (EP-CANN) and 21 healthy controls participated in this study. MMN/P3a was elicited using a two-tone, auditory paradigm with 8% duration deviants. RESULTS: As expected, EP-CANN showed marked reductions in MMN/P3a amplitudes compared to controls. However, EP + CANN showed evidence of a different pattern of neurophysiological expression of MMN/P3a compared to non-using patients, most notably in terms of delayed frontal MMN/P3a latencies. CONCLUSIONS: This study provides further evidence that MMN/P3a deficits are present during early psychosis and suggests that this biomarker may have utility in differentiating substance- from non-substance-related psychoses.
Nicole Pesa; Daniel F Hermens; Robert A Battisti; Manreena Kaur; Ian B Hickie; Nadia Solowij
Related Documents :
18305976 - Henoch schonlein purpura in childhood: clinical analysis of 254 cases over a 3-year per...
7057326 - Immune deposits and mesangial hypercellularity in minimal change nephrotic syndrome: cl...
2799296 - Cadmium concentration in human kidney biopsies.
10995526 - Circadian rhythm of blood pressure in renal disease.
19564556 - Preoperative hemoglobin level as a predictor of survival after coronary artery bypass g...
18559766 - Synergistic effect of broad-spectrum sunscreens and antihistamines in the control of id...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-9
Journal Detail:
Title:  Psychopharmacology     Volume:  -     ISSN:  1432-2072     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Psychology, University of Wollongong, Wollongong, NSW, 2522, Australia,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  PLMLA: prediction of lysine methylation and lysine acetylation by combining multiple features.
Next Document:  Synthesis, crystal structure, spectroscopic and electrochemical properties, and H(2)-evolving activi...