| Delayed parturition in cloned calves associated with persistently elevated placentomal TGF-beta1 expression. | |
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MedLine Citation:
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PMID: 19167845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to investigate hormonal and TGF-beta(1) characterizations of delayed parturition in the SCNT recipients (Korean native beef cattle: Hanwoo). The SCNT blastocysts produced by Hanwoo fetal fibroblast cells were transferred into the synchronized Hanwoo recipients. The artificially inseminated Hanwoo recipients (AI-R) were used as control. All AI-R were labored by natural delivery. The SCNT recipients (SCNT-R) with no signs of delivery were operated by Caesarean section. The blood and placentomes were collected during parturition. The weight of placentomes in SCNT-R (n=12, 301+/-41.22 g) was significantly higher than that of AI-R (n=10, 204.8+/-24.89 g) (p<0.05). There were significantly lower E2 (p<0.05) or higher P4 (p<0.01) and TGF-beta(1) (p<0.01) levels in the SCNT-R compared to that of AI-R, respectively. The SCNT-R showed a higher placentomal TGF-beta(1) protein level compared to that of AI-R (p<0.01). Interestingly, the TGF-beta(1) protein level in SCNT-R with normal delivery was dramatically decreased as same as AI-R, but it was highly maintained in C-sec at days 250 of pregnancy in AI-R. These results suggest that delayed parturition in clone calving may be associated with persistence of elevated TGF-beta-1 expression in late pregnancy. |
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Authors:
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Seongsoo Hwang; Yoo-Min Chang; Yeoung-Gyu Ko; Byoung-Chul Yang; Kwan-Sik Min; Jong-Taek Yoon; Whan-Gook Nho; Chang-Keun Kim; Hwan-Hoo Seong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-25 |
Journal Detail:
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Title: Animal reproduction science Volume: 115 ISSN: 1873-2232 ISO Abbreviation: Anim. Reprod. Sci. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7807205 Medline TA: Anim Reprod Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 290-5 Citation Subset: IM |
Affiliation:
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National Institute of Animal Science, Suwon, Gyeonggi-do 441-706, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Cell Culture Techniques Cloning, Organism / methods, veterinary Delivery, Obstetric / veterinary Estradiol / blood Female Fetus / physiology Insemination, Artificial / methods, veterinary Oocytes / cytology Organ Size Parturition / physiology* Placenta / anatomy & histology, metabolism* Pregnancy Pregnancy, Animal / physiology* Progesterone / blood Transforming Growth Factor beta1 / genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Transforming Growth Factor beta1; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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