Document Detail


Delayed parturition in cloned calves associated with persistently elevated placentomal TGF-beta1 expression.
MedLine Citation:
PMID:  19167845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to investigate hormonal and TGF-beta(1) characterizations of delayed parturition in the SCNT recipients (Korean native beef cattle: Hanwoo). The SCNT blastocysts produced by Hanwoo fetal fibroblast cells were transferred into the synchronized Hanwoo recipients. The artificially inseminated Hanwoo recipients (AI-R) were used as control. All AI-R were labored by natural delivery. The SCNT recipients (SCNT-R) with no signs of delivery were operated by Caesarean section. The blood and placentomes were collected during parturition. The weight of placentomes in SCNT-R (n=12, 301+/-41.22 g) was significantly higher than that of AI-R (n=10, 204.8+/-24.89 g) (p<0.05). There were significantly lower E2 (p<0.05) or higher P4 (p<0.01) and TGF-beta(1) (p<0.01) levels in the SCNT-R compared to that of AI-R, respectively. The SCNT-R showed a higher placentomal TGF-beta(1) protein level compared to that of AI-R (p<0.01). Interestingly, the TGF-beta(1) protein level in SCNT-R with normal delivery was dramatically decreased as same as AI-R, but it was highly maintained in C-sec at days 250 of pregnancy in AI-R. These results suggest that delayed parturition in clone calving may be associated with persistence of elevated TGF-beta-1 expression in late pregnancy.
Authors:
Seongsoo Hwang; Yoo-Min Chang; Yeoung-Gyu Ko; Byoung-Chul Yang; Kwan-Sik Min; Jong-Taek Yoon; Whan-Gook Nho; Chang-Keun Kim; Hwan-Hoo Seong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-25
Journal Detail:
Title:  Animal reproduction science     Volume:  115     ISSN:  1873-2232     ISO Abbreviation:  Anim. Reprod. Sci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807205     Medline TA:  Anim Reprod Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Affiliation:
National Institute of Animal Science, Suwon, Gyeonggi-do 441-706, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cell Culture Techniques
Cloning, Organism / methods,  veterinary
Delivery, Obstetric / veterinary
Estradiol / blood
Female
Fetus / physiology
Insemination, Artificial / methods,  veterinary
Oocytes / cytology
Organ Size
Parturition / physiology*
Placenta / anatomy & histology,  metabolism*
Pregnancy
Pregnancy, Animal / physiology*
Progesterone / blood
Transforming Growth Factor beta1 / genetics*,  metabolism
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta1; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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