Document Detail

Delayed ossification in Wistar rats induced by Morinda citrifolia L. exposure during pregnancy.
MedLine Citation:
PMID:  20038450     Owner:  NLM     Status:  MEDLINE    
Different products of plant Morinda citrifolia L. (noni) have been marketed and used around the world based on properties described by Polynesian people that use them for more than 2000 years. Marketing of these products is based on their presumptive phytotherapic properties. However there is little scientific evidence about their safety, especially when used during pregnancy. AIM OF THE STUDY: Evaluate the possible developmental toxicity of the noni fruit aqueous extract and commercial product of TAHITIAN NONI juice in rats exposed during pregnancy. MATERIALS AND METHODS: Pregnant Wistar rats were exposed by gavage to 7, 30 and 300 mg/kg bw (body weight) of noni aqueous extract or to 0.4, 2 and 20 mL/kg bw (body weight) of noni juice between day 7 and day 15 of pregnancy. Caesarean sections were performed on day 20 of pregnancy and reproductive parameters were evaluated. Implantations sites and postimplantation losses were recorded. Fetuses were weighted and examined for externally visible anomalies. After, the fetuses were cleared with KOH and the bones stained with alizarin red. Skeletal alterations of the skull, vertebral column, ribs, forelimbs, hindlimbs, sternum, sings of delayed ossification and variations were examined in accordance with pre-defined criteria and identified using harmonized and internationally accepted nomenclature recommended by the International Federation of Teratology Societies. RESULTS: Exposure with extract and juice of Morinda citrifolia did not induce maternal toxicity at the tested doses, but induced delayed ossification in fetuses. CONCLUSION: The exposure of pregnant rats to aqueous extract or juice Morinda citrifolia during organogenesis period may induce adverse effects on the normal development of fetuses. These findings indicate the need for further studies with noni derivates preceding their use in pregnant women.
Nelson Fernando Quallio Marques; Ana Paula Bombonatto Mariano Marques; Ana L?via Iwano; Munisa Golin; Rosangela Ribeiro De-Carvalho; Francisco Jos? Roma Paumgartten; Paulo Roberto Dalsenter
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-28
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  128     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Pharmacology, Federal University of Paran?, PO Box 19031, CEP 81531-990 Curitiba, Brazil.
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MeSH Terms
Bone Development / drug effects*
Dose-Response Relationship, Drug
Morinda / chemistry*
Plant Extracts / pharmacology*
Pregnancy Outcome
Rats, Wistar
Teratogens / pharmacology*
Reg. No./Substance:
0/Plant Extracts; 0/Teratogens

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