Document Detail

Delayed-onset muscle damage and lipid peroxidation in man after a downhill run.
MedLine Citation:
PMID:  2770784     Owner:  NLM     Status:  MEDLINE    
Lipid peroxidation initiated by free radical reactions is associated with tissue necrosis in a variety of conditions. We have measured serum lipid peroxide concentrations (as total thiobarbituric acid-reactive substances, TBARS) and creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) activities and subjective muscle soreness in 16 men before and after a 45-minute downhill treadmill run. TBARS concentrations and enzyme activities were increased after exercise, with peak values observed at 6 hours (TBARS, LDH) or 24 hours (CK, AST) after exercise. Serum LDH activity returned to preexercise levels by 48 hours after exercise and TBARS by 72 hours after exercise: CK and AST activities remained elevated 72 hours after exercise. Leg muscle soreness also increased, with the greatest degree of soreness seen at 24 or 48 hours after exercise. Subjects with the greatest increase in CK, LDH, and AST also showed the highest serum TBARS concentration. This suggests a possible relationship between free radical generation and exercise-induced muscle damage.
R J Maughan; A E Donnelly; M Gleeson; P H Whiting; K A Walker; P J Clough
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  12     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  332-6     Citation Subset:  IM; S    
Department of Environmental & Occupational Medicine, University Medical School, Aberdeen, UK.
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MeSH Terms
Creatine Kinase / metabolism
L-Lactate Dehydrogenase / metabolism
Lipid Peroxidation*
Muscles / metabolism*,  physiology
Physical Exertion*
Time Factors
Reg. No./Substance:
EC Dehydrogenase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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