Document Detail


Delayed ocular complications of mustard gas poisoning and the relationship with respiratory and cutaneous complications.
MedLine Citation:
PMID:  16764654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study was aimed to determine the correlation between ocular complications and respiratory or cutaneous complications in a group of 40 Iranian veterans with late complications of sulphur mustard (SM) poisoning. METHODS: Thorough ophthalmologic examination was performed on all severely SM-poisoned veterans in the province of Khorasan, Iran. Spirometric evaluation of pulmonary function, as well as estimation of the burned skin area, was performed for all the patients. The severities of ocular, respiratory and cutaneous complications were classified into four grades in each patient and were compared with each other, using Spearman's rank correlation test. RESULTS: Forty male patients (aged 43.8 +/- 9.8 years) with confirmed SM poisoning were studied 16-20 years after their initial exposure. Common symptoms were recorded as itching (42.5%), burning sensation (37.5%), photophobia (30%) and tearing (27.5%). Abnormal conjunctival and limbal findings were chronic conjunctivitis (17.5%), perilimbal hyperpigmentation (17.5%), vascular tortuosity (15%) and limbal ischaemia (12.5%). Abnormal corneal findings were subepithelial opacity (15%), corneal thinning (15%), diffuse corneal opacity (10%), neovascularization (7.5%) and epithelial defects (5%). A significant positive correlation was found between the severity of ocular and respiratory complications (r = 0.322, P = 0.043). Cutaneous complications revealed no significant correlation with either ocular or respiratory complications. CONCLUSIONS: SM causes delayed destructive lesions in the ocular surface and cornea, leading to progressive visual deterioration and ocular irritation. Late complications of SM poisoning in the eyes, respiratory system and skin are mainly due to SM's local irritant effects.
Authors:
Mohammad Etezad-Razavi; Mahmoud Mahmoudi; Mehrdad Hefazi; Mahdi Balali-Mood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  34     ISSN:  1442-6404     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
Affiliation:
Ophthalmology Department, Khatamolanbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. metezadr2003@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Burns, Chemical / etiology*
Chemical Warfare Agents / poisoning*
Conjunctival Diseases / chemically induced
Corneal Diseases / chemically induced
Eye Burns / chemically induced
Eye Diseases / chemically induced*
Humans
Iran
Male
Middle Aged
Mustard Gas / poisoning*
Respiratory Function Tests
Respiratory Tract Diseases / chemically induced*
Skin Diseases / chemically induced*
Veterans*
Chemical
Reg. No./Substance:
0/Chemical Warfare Agents; 505-60-2/Mustard Gas

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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