Document Detail


Delayed maturation of the vagus nerve in sudden infant death syndrome.
MedLine Citation:
PMID:  8310817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abnormalities of the respiratory control system have been implicated in the cause of death in sudden infant death syndrome (SIDS). The vagus nerve is a major component of the neural regulation of respiration. Ultrastructural quantitative morphometry of myelinated and unmyelinated fibers was performed on cervical vagus nerves taken from 30 SIDS victims and 29 age-matched controls between 1 and 9 months of age. In SIDS infants, more small and fewer large myelinated vagal fibers were found than in controls, suggesting that the vagus nerve in SIDS is relatively immature. Delayed vagal nerve maturation, together with delays in central nervous system myelination and dendritic development, indicates a neural developmental delay in SIDS, the cause of which is undetermined.
Authors:
L E Becker; W Zhang; P M Pereyra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neuropathologica     Volume:  86     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-17     Completed Date:  1994-03-17     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  IM    
Affiliation:
Department of Pathology (Neuropathology), University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Humans
Infant
Nerve Fibers / pathology,  ultrastructure
Nerve Fibers, Myelinated / pathology,  ultrastructure
Sudden Infant Death / etiology,  pathology*
Vagus Nerve / growth & development,  pathology*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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