Document Detail


Delayed maturation of IgG avidity in congenital toxoplasmosis.
MedLine Citation:
PMID:  15558340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this comparative study was to investigate the clinical usefulness of the measurement of Toxoplasma gondii IgG avidity in the postnatal diagnosis of congenital toxoplasmosis. IgG avidity values in serum samples from infants with congenital infection were compared with those in samples from uninfected infants, all born to mothers with toxoplasmosis acquired during gestation. This analysis revealed that IgG avidity values soon after birth reflected maternal values in the large majority of the samples. Low or borderline IgG avidity values were systematically found in the cohort of congenitally infected subjects. After birth, IgG avidity values slowly increased over time for up to 2 years in congenitally infected subjects. On the contrary, IgG avidity values in the uninfected infants remained stable over time. The presence of low IgG avidity in a newborn can be considered a marker of maternal seroconversion in the second or third trimester of gestation and, as a consequence, an indicator of risk for congenital toxoplasmosis. An IgG avidity assay can be easily carried out with antibodies eluted from dried blood spots (Guthrie cards), providing an opportunity to retrospectively evaluate the risk of congenital infection in special clinical circumstances, for example when suspicion of congenital infection arises during late infancy.
Authors:
W Buffolano; M Lappalainen; L Hedman; F Ciccimarra; M Del Pezzo; R Rescaldani; N Gargano; K Hedman
Publication Detail:
Type:  Journal Article     Date:  2004-10-19
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  23     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  825-30     Citation Subset:  IM    
Affiliation:
Pediatrics Department, Federico II Naples University, via Pansini 5, 80131 Naples, Italy. wilma@unina.it
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MeSH Terms
Descriptor/Qualifier:
Aging / immunology
Antibodies, Protozoan / blood,  immunology*
Antibody Affinity
Child, Preschool
Female
Humans
Immunoglobulin G / blood,  immunology*
Infant
Infant, Newborn
Pregnancy
Pregnancy Trimesters
Retrospective Studies
Toxoplasmosis, Congenital / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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