Document Detail

Delayed low-dose supplemental oxygen improves survival following phosgene-induced acute lung injury.
MedLine Citation:
PMID:  20384554     Owner:  NLM     Status:  MEDLINE    
Phosgene is a chemical widely used in the plastics industry and has been used in warfare. It produces life-threatening pulmonary edema within hours of exposure; no antidote exists. This study examines pathophysiological changes seen following treatment with elevated inspired oxygen concentrations (Fi(O2)), in a model of phosgene-induced acute lung injury. Anesthetized pigs were exposed to phosgene (Ct 2500 mg min m(-3)) and ventilated (intermittent positive pressure ventilation, tidal volume 10 ml kg(-1), positive end-expiratory pressure 3 cm H(2)O, frequency 20 breaths min(-1)). The Fi(O2) was varied: group 1, Fi(O2) 0.30 (228 mm Hg) throughout; group 2, Fi(O2) 0.80 (608 mm Hg) immediately post exposure, to end; group 3, Fi(O2) 0.30 from 30 min post exposure, increased to 0.80 at 6 h post exposure; group 4, Fi(O2) 0.30 from 30 min post exposure, increased to 0.40 (304 mm Hg) at 6 h post exposure. Group 5, Fi(O2) 0.30 from 30 min post exposure, increased to 0.40 at 12 h post exposure. The current results demonstrate that oxygen is beneficial, with improved survival, arterial oxygen saturation, shunt fraction, and reduced lung wet weight to body weight ratio in all treatment groups, and improved arterial oxygen partial pressure in groups 2 and 3, compared to phosgene controls (group 1) animals. The authors recommend that treatment of phosgene-induced acute lung injury with inspired oxygen is delayed until signs or symptoms of hypoxia are present or arterial blood oxygenation falls. The lowest concentration of oxygen that maintains normal arterial oxygen saturation and absence of clinical signs of hypoxia is recommended.
C Grainge; B J Jugg; A J Smith; R F R Brown; J Jenner; D A Parkhouse; P Rice
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  22     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2011-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  552-60     Citation Subset:  IM    
Institute of Naval Medicine, Alverstoke, UK.
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MeSH Terms
Acute Lung Injury / chemically induced*,  pathology,  therapy*
Administration, Inhalation
Oxygen / administration & dosage
Oxygen Inhalation Therapy / methods*
Phosgene / toxicity*
Survival Rate / trends
Sus scrofa
Time Factors
Reg. No./Substance:
75-44-5/Phosgene; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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