Document Detail

Delayed hypersensitivity to human encephalitogenic protein as assayed by agarose leucocyte migration in multiple sclerosis patients.
MedLine Citation:
PMID:  90126     Owner:  NLM     Status:  MEDLINE    
Using a leucocyte migration test (Clausen's direct agarose gel migration method) hypersensitivity to human encephalitogenic protein has been examined in 50 multiple sclerosis patients (group 1), 50 healthy persons (group 2) and 25 patients with other neurological diseases (group 3). In group 1, 30 MS patients (60%) show an abnormal migration index, manifested either as inhibition or stimulation of migration; 29 controls in group 2 (58%), 11 O.N.D. patients in group 3 (44%) show an abnormal migration index. These results mean that lymphocyte hypersensitivity to myelin basic protein appears neither to be constant nor specific to multiple sclerosis. Three migration index curve types at different antigen concentration are obtained: monophasic curves within the normal index zones; monophasic curves staying in the inhibition or stimulation zone and biphasic curves with dose-effect relationship. Whatever the antigen used, this dose-effect relationship implies that the test must be carried out at different concentrations. The meaning of spontaneous sensitisation in healthy controls is discussed.
M Clanet; E Kuhlein; A Rascol; M Abbal; E Ohayon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  42     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-13     Citation Subset:  IM    
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MeSH Terms
Age Factors
Cell Migration Inhibition
Cell Movement
Dose-Response Relationship, Immunologic
Hypersensitivity, Delayed / complications*
Lymphocytes / immunology*
Middle Aged
Multiple Sclerosis / complications*
Myelin Basic Proteins / immunology*
Sex Factors
Reg. No./Substance:
0/Myelin Basic Proteins; 9012-36-6/Sepharose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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