Document Detail

Delayed hyperbaric oxygenation is more effective than early prolonged normobaric hyperoxia in experimental focal cerebral ischemia.
MedLine Citation:
PMID:  17850964     Owner:  NLM     Status:  MEDLINE    
Hyperbaric (HBO) and normobaric (NBO) oxygen therapy have been shown to be neuroprotective in focal cerebral ischemia. In previous comparative studies, NBO appeared to be less effective than HBO. However, the experimental protocols did not account for important advantages of NBO in the clinical setting such as earlier initiation and prolonged administration. Therefore, we compared the effects of early prolonged NBO to delayed HBO on infarct size and functional outcome. We also examined whether combining NBO and HBO is of additional benefit. Wistar rats underwent filament-induced middle cerebral artery occlusion (MCAO) for 150 min. Animals breathed either air, 100% O(2) at ambient pressure (NBO; initiated 30 min after MCAO) 100% O(2) at 3 atm absolute (HBO; initiated 90 min after MCAO), or a sequence of NBO and HBO. Infarct volumes and neurological outcome (Garcia score) were examined 7d after MCAO. HBO (174+/-65 mm(3)) significantly reduced mean infarct volume by 31% compared to air (251+/-59 mm(3)) and by 23% compared to NBO treated animals (225+/-63 mm(3)). In contrast, NBO failed to decrease infarct volume significantly. Treatment with NBO+HBO (185+/-101 mm(3)) added no additional benefit to HBO alone. Neurological deficit was significantly smaller in HBO treated animals (Garcia score: 13.3+/-1.2) than in animals treated with air (12.1+/-1.4), but did not differ significantly from NBO (12.4+/-0.9) and NBO+HBO (12.8+/-1.1). In conclusion, HBO is a more effective therapy than NBO in transient experimental ischemia even when accounting for delayed treatment-onset of HBO. The combination of NBO and HBO results in no additional benefit.
Christopher Beynon; Li Sun; Hugo H Marti; Sabine Heiland; Roland Veltkamp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-01
Journal Detail:
Title:  Neuroscience letters     Volume:  425     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Department of Neurology, University of Heidelberg, Germany.
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MeSH Terms
Atmosphere Exposure Chambers / standards,  trends
Brain / metabolism*,  physiopathology
Brain Infarction / physiopathology,  therapy*
Brain Ischemia / physiopathology,  therapy*
Cerebrovascular Circulation / physiology
Emergency Medical Services / methods,  standards
Hyperbaric Oxygenation / methods*,  standards
Hyperoxia / metabolism*
Infarction, Middle Cerebral Artery / physiopathology,  therapy
Oxygen / administration & dosage*
Oxygen Inhalation Therapy / methods,  standards
Rats, Wistar
Time Factors
Treatment Outcome
Reg. No./Substance:

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