Document Detail

Delayed high-quality CPR does not improve outcomes.
MedLine Citation:
PMID:  22208179     Owner:  NLM     Status:  Publisher    
AIM OF STUDY: The quality of cardiopulmonary resuscitation (CPR) is an important factor in the outcome of cardiac arrest. Our objective was to compare outcomes following either immediate low-quality (LQ) CPR or delayed high-quality (HQ) CPR. We hypothesized that delayed HQ CPR will improve the outcomes of CPR in comparison to immediately performing LQ CPR. METHODS: Eighteen Sprague-Dawley rats were randomized into two groups: (1) Delayed HQ CPR (HQ group, n = 9). (2) Immediate LQ CPR (LQ group, n = 9). Ventricular fibrillation (VF) was induced and untreated for 8 mins. CPR was immediately performed in LQ group for 5 mins. Compression depth was set at 70% of the "optimal compression depth". VF was untreated for an additional 5 mins in HQ group. HQ CPR was started together with ventilation (100% oxygen) and external hypothermia for 8 mins in both groups. The "optimal compression depth" was approximately 30% of the anteroposterior chest diameter. Epinephrine was administrated 3 mins prior to defibrillation attempt. Restoration of spontaneous circulation, postresuscitation myocardial function and survival time were monitored. RESULTS: All animals in the LQ group and 7 of 9 animals in the HQ group were resuscitated. Myocardial function, including ejection fraction and cardiac output was better in the LQ group than in the HQ group (p < 0.05) and survival time was longer in the LQ group (p < 0.05). CONCLUSION: The outcomes after immediate LQ CPR, were better than those after delayed HQ CPR in this rat model of cardiac arrest and resuscitation.
Fengqing Song; Shijie Sun; Giuseppe Ristagno; Tao Yu; Yi Shan; Sung Phil Chung; Max Harry Weil; Wanchun Tang
Related Documents :
15296889 - Prophylactic tranexamic acid in elective, primary coronary artery bypass surgery using ...
20630919 - Dutch perfusion incident survey.
2369199 - Comparative study of cell saver and ultrafiltration nontransfusion in cardiac surgery.
19282749 - Clinical application of pulsatile perfusion during cardiopulmonary bypass in pediatric ...
11208399 - Low doses of aprotinin in aortocoronary bypass surgery--advantages and disadvantages.
382479 - The evaluation of hemorrhage in cardiac patients who have undergone extracorporeal circ...
6657189 - Discriminant analysis of acquired esotropia surgery. predictor variables for short- and...
12854019 - Retroequatorial recession of horizontal recti with loop suture in the treatment of cong...
9851489 - Acoustic and perceptual evaluation of laryngeal reinnervation by ansa cervicalis transfer.
Publication Detail:
Journal Detail:
Title:  Resuscitation     Volume:  82S2     ISSN:  1873-1570     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  S52-S55     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Post-cardiac arrest hyperoxia and mitochondrial function.
Next Document:  Shock advisory system with minimal delay triggering after end of chest compressions: Accuracy and ga...