Document Detail


Delayed habituation in Behcet's disease.
MedLine Citation:
PMID:  18310833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The autonomic nervous system in Behcet's patients may be affected due to various reasons. This entity may be detected with the measurement of the electrodermal activities, heart rate variability and pupillometric methods. Habituation is one of the implicit forms of learning and memory and the loss of habituation can reveal pathological changes in the synaptic regions. AIM: To determine whether there is a functional decrease in the synaptic effectiveness (habituation) of the pathways to sympathetic neurons that had been repeatedly activated in Behcet's. MATERIALS AND METHODS: Twelve patients with Behcet's disease and 12 healthy controls were included in the study. Sympathetic skin potential (SSP) records were taken at normal room temperature in a quiet place within a Faraday cage. Sixteen square wave single shock impulses (duration: 1200 ms, strength: 5 mA) were applied on each case. RESULTS: After the 1st stimulus, the SSP amplitudes were lower in the patients compared to the controls (P<0.001, t value=7.69). There was no significant differences among the SSP amplitudes after the 13th impulse in the patients (P>0.05). Whereas there was no significant differences among the SSP amplitudes after the 9th impulse in the controls (P>0.05). The habituation rate of the SSP after consecutive impulses was slowest in the patients compared to controls (P<0.001, t value=12.39). CONCLUSIONS: There is a delayed habituation in Behcet's disease and that may due to pathologic changes with vasculitis through their peripheral nerves.
Authors:
Sefa Gulturk; Melih Akyol; Hulusi Kececi; Sedat Ozcelik; Ziynet Cinar; Ayse Demirkazik
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurology India     Volume:  56     ISSN:  0028-3886     ISO Abbreviation:  Neurol India     Publication Date:    2008 Jan-Mar
Date Detail:
Created Date:  2008-03-03     Completed Date:  2009-06-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0042005     Medline TA:  Neurol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  27-30     Citation Subset:  IM    
Affiliation:
Department of Physiology, Cumhuriyet University School of Medicine, Sivas, Turkey. sgulturk@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Behcet Syndrome / complications*
Electroshock / methods
Female
Galvanic Skin Response* / physiology
Habituation, Psychophysiologic / physiology*
Humans
Male
Middle Aged
Reaction Time / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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