Document Detail

Delayed graft rejection in pre-vascularised corneas after subconjunctival injection of clodronate liposomes.
MedLine Citation:
PMID:  10806446     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To test the effects of clodronate liposomes on graft survival and neovascularisation after transplantation in pre-vascularised recipient corneas. METHODS: Corneal neovascularisation was induced in F344 rats by injecting heat inactivated rabbit serum intrastromally. After 4 weeks F344 rats were orthotopically grafted with corneal buttons from DA rats. Directly after transplantation and on 2, 4, 6 and 8 days postoperatively clodronate liposomes were administrated subconjunctivally in one group, whereas the other group remained untreated. For 60 days grafts were observed for signs of graft rejection and neovascularisation. RESULTS: Graft survival was significantly prolonged, but not prevented in clodronate liposome treated rats compared to untreated rats ( p =.004). Also clodronate liposome administration delays growth of corneal neovascularisation after transplantation. CONCLUSIONS: Previous studies revealed that clodronate liposomes prevent corneal graft rejection and reduce neovascularisation in orthotopic corneal allotransplantation in rats. This study shows that also in pre-vascularised recipient corneas subconjunctival administration of clodronate liposomes seems to delay corneal graft rejection and reduces neovascularisation.
T P Slegers; N van Rooijen; G van Rij; R van der Gaag
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  20     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-29     Completed Date:  2000-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  322-4     Citation Subset:  IM    
Department of Ophthalmology, Groningen University Hospital, Groningen, The Netherlands.
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MeSH Terms
Clodronic Acid / administration & dosage*,  therapeutic use
Cornea / blood supply*
Corneal Transplantation*
Drug Carriers
Graft Rejection / prevention & control*
Neovascularization, Pathologic / etiology,  prevention & control
Rabbits / blood
Rats, Inbred F344
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
0/Drug Carriers; 0/Liposomes; 10596-23-3/Clodronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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