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Delayed gastric emptying using (13) C octanoic acid breath test in systemic sclerosis.
MedLine Citation:
PMID:  22231388     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The aims of this prospective study were to: 1) determine the prevalence of delayed gastric emptying in unselected SSc patients, using (13) C octanoic acid breath test; 2) evaluate whether the findings of (13) C octanoic acid breath test are associated with: (i) digestive clinical manifestations, gastric mucosal abnormalities on gastroscopy and antro-duodenal motor activity dysfunction on manometry, and (ii) esophageal motor impairment and extra-digestive manifestations of SSc; and 3) develop a risk prediction score of gastric emptying in SSc. PATIENTS AND METHODS: 57 consecutive patients with SSc underwent (13) C octanoic acid breath test. All SSc patients also completed a questionnaire for digestive symptoms, and a global symptomatic score was calculated. RESULTS: The prevalence of delayed gastric emptying was 47.8% in our SSc patients. We observed a marked correlation between values of global symptomatic score of digestive symptoms ≥ 5 and the presence of delayed gastric emptying (p<10(-6) ); both sensibility and specificity of global symptomatic score ≥ 5 to predict delayed gastric emptying were as high as 0.93 and 0.73, respectively. Moreover, global symptomatic score ≥ 5, mucosal gastric abnormalities, severe esophageal motor impairment and interstitial lung disease were: 1) independently associated with the presence of delayed gastric emptying; and 2) used to create a predictive score. The area under the ROC curve was 0.9; both sensitivity and specificity of this latter score were 0.93 and 0.77, respectively. CONCLUSION: Our study underscores that delayed gastric emptying often occurs in SSc patients. Interestingly, using routine clinical observations, we identified a simple score which predicted the presence of delayed gastric emptying in SSc patients.
I Marie; G Gourcerol; A-M Leroi; J-F Ménard; H Levesque; P Ducrotté
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-9
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Department of Internal Medicine, Rouen University Hospital, 76301 Rouen Cedex, France.
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