| Delayed gastric emptying using (13) C octanoic acid breath test in systemic sclerosis. | |
| | |
MedLine Citation:
|
PMID: 22231388 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: The aims of this prospective study were to: 1) determine the prevalence of delayed gastric emptying in unselected SSc patients, using (13) C octanoic acid breath test; 2) evaluate whether the findings of (13) C octanoic acid breath test are associated with: (i) digestive clinical manifestations, gastric mucosal abnormalities on gastroscopy and antro-duodenal motor activity dysfunction on manometry, and (ii) esophageal motor impairment and extra-digestive manifestations of SSc; and 3) develop a risk prediction score of gastric emptying in SSc. PATIENTS AND METHODS: 57 consecutive patients with SSc underwent (13) C octanoic acid breath test. All SSc patients also completed a questionnaire for digestive symptoms, and a global symptomatic score was calculated. RESULTS: The prevalence of delayed gastric emptying was 47.8% in our SSc patients. We observed a marked correlation between values of global symptomatic score of digestive symptoms ≥ 5 and the presence of delayed gastric emptying (p<10(-6) ); both sensibility and specificity of global symptomatic score ≥ 5 to predict delayed gastric emptying were as high as 0.93 and 0.73, respectively. Moreover, global symptomatic score ≥ 5, mucosal gastric abnormalities, severe esophageal motor impairment and interstitial lung disease were: 1) independently associated with the presence of delayed gastric emptying; and 2) used to create a predictive score. The area under the ROC curve was 0.9; both sensitivity and specificity of this latter score were 0.93 and 0.77, respectively. CONCLUSION: Our study underscores that delayed gastric emptying often occurs in SSc patients. Interestingly, using routine clinical observations, we identified a simple score which predicted the presence of delayed gastric emptying in SSc patients. |
| | |
Authors:
|
I Marie; G Gourcerol; A-M Leroi; J-F Ménard; H Levesque; P Ducrotté |
Related Documents
:
|
22563198 - Differences between diffuse and focal autoimmune pancreatitis. 11241228 - Acquired bleeding disorder in a patient with malignant lymphoma: antibody-mediated prot... 6403138 - Treatment of haemophilia and related disorders in britain and northern ireland during 1... 16122628 - Coagulation system activated in duchenne muscular dystrophy patients with cardiac dysfu... 10783228 - Pericardial and pleural effusions in decompensated chronic heart failure. 11296098 - Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-in... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
|
Title: Arthritis and rheumatism Volume: - ISSN: 1529-0131 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 by the American College of Rheumatology. |
Affiliation:
|
Department of Internal Medicine, Rouen University Hospital, 76301 Rouen Cedex, France. isabelle.marie@chu-rouen.fr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hyperinsulinaemic hypoglycaemia: genetic mechanisms, diagnosis and management.
Next Document: Al(2)O(3)(112[combining macron]0) surface as a template for the ordered growth of Ni and Co nanoclus...