Document Detail

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and morphologic MRI of cartilage in the long-term follow-up after Legg-Calvé-Perthes disease (LCPD).
MedLine Citation:
PMID:  21696558     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The purpose of the present study was to evaluate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the detection of cartilage changes versus morphologic imaging in the long-term course of Legg-Calvé-Perthes disease (LCPD).
METHODS: A total of 31 hips in 26 patients (mean age, 30.0years; range, 18-54years) who were diagnosed with LCPD in childhood were included. Twenty-one radiographically normal contralateral hips served as controls. dGEMRIC indices of femoral and acetabular cartilage in the weight-bearing zone. Cartilage morphology was classified on radial PD-weighted images according to the modified Outerbridge classification.
RESULTS: Mean dGEMRIC values of cartilage were significantly lower in hips after LCPD than in the radiographically normal contralateral hips (513±100 ms vs. 579±103 ms; P=0.026). In 24 out of 31 LCPD hips and in 4 out of 21 radiographically normal contralateral hips, morphological cartilage changes were noted. Analysis of variance analysis revealed a significant influence of Outerbridge grading on decreased T1-values (P=0.031).
CONCLUSION: Our results suggest that dGEMRIC at 1.5 T is suitable to assess cartilage quality changes in the long-term follow-up after LCPD. The evaluation of biochemical cartilage quality with dGEMRIC may provide additional information about early cartilage changes occurring without visible alterations of cartilage morphology.
Arne Holstein; Christoph Zilkens; Bernd Bittersohl; Marcus Jäger; Tanja Haamberg; Tallal C Mamisch; Rotem S Lanzman; Patric Kröpil; Dirk Blondin; Rüdiger Krauspe; Gerald Antoch; Günther Fürst; Falk Miese
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical imaging and radiation oncology     Volume:  55     ISSN:  1754-9485     ISO Abbreviation:  J Med Imaging Radiat Oncol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-23     Completed Date:  2011-11-03     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101469340     Medline TA:  J Med Imaging Radiat Oncol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists.
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MeSH Terms
Cartilage, Articular / pathology*
Contrast Media*
Gadolinium DTPA / diagnostic use*
Legg-Calve-Perthes Disease / pathology*
Magnetic Resonance Imaging*
Middle Aged
Young Adult
Reg. No./Substance:
0/Contrast Media; K2I13DR72L/Gadolinium DTPA

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