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Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and morphologic MRI of cartilage in the long-term follow-up after Legg-Calvé-Perthes disease (LCPD).
MedLine Citation:
PMID:  21696558     Owner:  NLM     Status:  In-Data-Review    
Introduction: The purpose of the present study was to evaluate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the detection of cartilage changes versus morphologic imaging in the long-term course of Legg-Calvé-Perthes disease (LCPD). Methods: A total of 31 hips in 26 patients (mean age, 30.0 years; range, 18-54 years) who were diagnosed with LCPD in childhood were included. Twenty-one radiographically normal contralateral hips served as controls. dGEMRIC indices of femoral and acetabular cartilage in the weight-bearing zone. Cartilage morphology was classified on radial PD-weighted images according to the modified Outerbridge classification. Results: Mean dGEMRIC values of cartilage were significantly lower in hips after LCPD than in the radiographically normal contralateral hips (513 ± 100 ms vs. 579 ± 103 ms; P = 0.026). In 24 out of 31 LCPD hips and in 4 out of 21 radiographically normal contralateral hips, morphological cartilage changes were noted. Analysis of variance analysis revealed a significant influence of Outerbridge grading on decreased T1-values (P = 0.031). Conclusion: Our results suggest that dGEMRIC at 1.5 T is suitable to assess cartilage quality changes in the long-term follow-up after LCPD. The evaluation of biochemical cartilage quality with dGEMRIC may provide additional information about early cartilage changes occurring without visible alterations of cartilage morphology.
Arne Holstein; Christoph Zilkens; Bernd Bittersohl; Marcus Jäger; Tanja Haamberg; Tallal C Mamisch; Rotem S Lanzman; Patric Kröpil; Dirk Blondin; Rüdiger Krauspe; Gerald Antoch; Günther Fürst; Falk Miese
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical imaging and radiation oncology     Volume:  55     ISSN:  1754-9485     ISO Abbreviation:  J Med Imaging Radiat Oncol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469340     Medline TA:  J Med Imaging Radiat Oncol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists.
Department of Diagnostic and Interventional Radiology Department of Orthopaedics, University Hospital Düsseldorf, Medical Faculty, Düsseldorf, Germany Department of Orthopaedic Surgery, University Hospital Bern, Bern, Switzerland.
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